Effect of Intrahypothalamic Implantation of Dibenamine on Milk-Ejection Reflex in Lactating Rats

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The present study was made to determine whether or not an adrenergic relay at the levels of the paraventricular nucleus and of the median eminence participated in regulation of the milk-ejection reflex by utilizing the implantation of dibenamine in lactating rats. In animals bearing dibenamine in the paraventricular nucleus, the litter weight gain on the day following the operation was slightly less than the corresponding value observed in the control animal bearing cholesterol in the same nucleus. The amount of additional milk obtained by the injection of oxytocin was about 2 times higher in the dibenamine implanted animals than in the cholesterol implanted animals, although the difference was not significant. These results suggest that adrenergic nerves terminating at the level of the paraventricular nucleus seem not to play an important role in the regulation of the milk-ejection reflex in rats. The amount of milk obtained by the litters suckling the animals bearing dibenamine in the median eminence was similar to that in the cholesterol implanted controls on the day following the operation. Thus, it is likely that dibenamine in the median eminence did not inhibit the milk-ejection reflex. Systemic administration of dibenamine blocked the milk-ejection reflex. This blockade was overcome by subsequent injection of oxytocin. Therefore, the main site of action of dibenamine to prevent the milk-ejection reflex may occur somewhere along the ascending paths of the suckling stimulus, but not at the level of the paraventricular nucleus, the median eminence and on the myoepithelial cells. The possibility that dibenamine may block the secretion of milk was also discussed.
社団法人日本内分泌学会の論文

Effect of Intrahypothalamic Implantation of Dibenamine on Milk-Ejection Reflex in Lactating Rats

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