The effect of 2-deoxy-D-glucose on insulin release by neonatal rat B cells in culture.
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概要
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The culture for 7days in medium with 5.5mM glucose and 1mM 2-deoxy-Dglucose enhanced the glucose sensitivity of neonatal rat B cells, and even stimulated their growth in vitro. Also, 2-deoxy-D-glucose supplementation maintained insulin release evoked by leucine and 2-ketoisocaproate from B cells at day 7 at levels several times higher than at day 1. The effect of leucine was greatly augmented by glutamine, whereas that of the 2-keto acid remained almost unchanged irrespective of the presence of glutamine. These results suggest an increase in oxidative catabolism of medium nutrients in B cells grown in medium with 2-deoxy-D-glucose for 7days, and such metabolic changes may promote the growth of B cells in vitro.
- 社団法人 日本内分泌学会の論文
著者
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KAGAWA SHOHEI
Department of Clinical Pathology and Clinical Laboratory, Hyogo College of Medicine
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Matsuoka Akira
Department Of Clinical Labolatory And Clinical Pathology Hyogo College Of Medicine
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Kagawa Shohei
Department Of Clinical Pathology And Clinical Laboratory Hyogo College Of Medicine
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Yoshida Keiko
Department Of Biology Faculty Of Science Niigata University
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WAKABAYASHI SHIGERU
Department of Clinical Pathology and Clinical Laboratory, Hyogo College of Medicine
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NAKAO KEIKO
Department of Clinical Pathology and Clinical Laboratory, Hyogo College of Medicine
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JHA BHARAT
Tribhuvan University, Institute of Medicine, Central Medicine Campus
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Shimizu Shizuo
Department of Clinical Pathology and Clinical Laboratory, Hyogo College of Medicine
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