Effects of Electric Stress on Glucose Metabolism, Glucose-Stimulated Cyclic Adenosine 3, 5-Monophosphate Accumulation and <SUP>45</SUP>Ca<SUP>++</SUP> Efflux in Isolated Pancreatic Islets from Rats Fed with a High Fat Diet
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概要
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The effects of the electric stress on glucose oxidation, cyclic adenosine 3, 5-monophosphate (AMP) accumulation and <SUP>45</SUP>Ca<SUP>++</SUP> efflux in response to glucose were studied in pancreatic islets isolated from rats fed on a control (C) or a high fat diet (F) for 12 weeks.<BR>The half of rats on each diet were subjected to electrical shocks in the random time schedule for1hr per day for the last 3 weeks of the feeding period (group C-S and F-S). The remaining rats were not given any shocks (group C-NS and F-NS). The rats in F-S group had the high levels of plasma epinephrine, dopamine and blood glucose. The basal content of cyclic AMP after 20min of incubation with 2.8mm glucose was decreased in islets from F-S group without affecting insulin release. After 20min of incubation with 25mm glucose, the cyclic AMP content in islets from F-S group, which was identical with that in F-NS group, was only 50% of that in C-S group. Insulin release in response to high glucose was significantly inhibited in islets from F-S group. In spite of a remarkable increase of cyclic AMP content in islets from C-S group, insulin release did not differ from that in C-NS group. Glucose (16.7mm)-stimulated <SUP>45</SUP>Ca<SUP>++</SUP>efflux from the perfused islets was greatly inhibited by the high fat diet rather than by stress. The rate of glucose oxidation with 16.7mm glucose was decreased in islets from F-S group.<BR>It is suggested that the decreased insulin release in response to glucose provoked by the combined effects of the feeding of a high fat diet and electric stress may be mediated by changes of the adenylate cyclase-cyclic AMP system on the plasma membrane of the B-cell or be related to changes in glucose metabolism in islets.
- 社団法人 日本内分泌学会の論文
著者
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Goko Hideki
Department Of Medical Technology Kobe University School Of Medicine
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Yamaguchi Keiko
Department Of Food And Nutrition Japan Women's University
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Matsuoka Akira
Department Of Clinical Pathology And Clinical Laboratories Hyogo College Of Medicine
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Yamaguchi Keiko
Department Of Dermatology Kagoshima University Faculty Of Medicine
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Matsuoka Akira
Department Of Clinical Labolatory And Clinical Pathology Hyogo College Of Medicine
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