Basic construction of the functional system in a protein : I. Functional system of modified trypsin (m-trypsin)
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概要
- 論文の詳細を見る
Modified trypsin (m-trysin) (essential amino acids for human in trypsin are neglected by replacing them with G (dummy)) was analysed by DEV model. It was found that the proteolytic functional system of trypsin could be assigned with m-trypsin and essential amino acids are not necessary in this step. Similar results were obtained with m-RNase and non-polar trypsin. These results suggest that the basic plan in the construction of trypsin or RNase can be made from non-polar or non-essential amino acids. The possible involvement of water is also discussed. Further discussion on the basic plan clarified the necessity for large DEV and DD values. Large DEV values for site B can be attained mainly by large n(z) values in formula [1] and are neutralized by large DD values from site E.
- 日本学士院の論文
著者
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KIHO Yukio
Ishihara Sangyo Kaisha, Ltd.
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PALMER Christopher
Ishihara Sangyo Kaisha, Ltd.
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ITO Masami
Toneyama Hospital
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IWAI Tsuruji
Kansai Medical University
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