Functional Word in a protein : IV. Alphabet
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概要
- 論文の詳細を見る
A unique nucleotide sequence that consists of aligned second bases of colon triplets in the cDNA sequence of trypsin is designed to identify the active sites on the DEV model. Compared with the amino acid sequence that was exploited before, the assignment of functional system or active sites of trypsin is straightforward: the site B and its partners, site E, contain 84-D, 40-H, and 177-S. However, the difficulty is in less-specific nature of the site Es that require information on amino acid sequence. The results led by means of either amino acid sequence or nucleotide sequence due to the difference in the number of alphabets (twenty amino acidsversus four nucleotides) and the prediction efficiency is strengthened by using these two words. Further improvement of the prediction can be done by artificial five alphabets, A, T, G, C, and S. In this case, information of cDNA is not necessary.
- 日本学士院の論文
著者
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KIHO Yukio
Ishihara Sangyo Kaisha, Ltd.
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IWAI Tsuruji
Kansai Medical University
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UBASAWA Aiko
Woodward Laboratory
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OKABE Yasunori
University of Tokyo
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UBASAWA Akiko
Woodward Laboratory
関連論文
- Basic construction of the functional system in a protein : I. Functional system of modified trypsin (m-trypsin)
- Functional Word in Protein : VI. Recognition
- Functional Word in a Protein : V. Comparative Linguistics
- Blobogical information transfer in a protein : II. Protein-protein interaction
- Biological information transfer in a protein : I. Closed circuit
- Basic construction of the functional system in a protein : III. Information transfer in a closed circuit
- Dynamic aspects of protein function : III. Comparison of homologous proteins isolated from various species
- Dynamic aspects of protein function : I. Rationale of mathematical approach
- Application of the Jellyfish Model : II. Higher Dimensional Structure of Trypsin
- Application of the Jellyfish Model : I. Virulency of Some Mammalian Viruses
- Basic construction of the functional system in a protein : II. Functional system of chymotrypsin
- Functional Word in a protein : IV. Alphabet
- Dynamic aspects of protein function : II. Metastable functional system of trypsin
- Functional Word in a Protein. III. Syntax and Energetics.:III. Syntax and Energetics
- A Simple Way to Identify Functional Sites in Protein III. Application of DEV Analysis to Proteins Other than Trypsin.:III. Application of DEV Analysis to Proteins Other than Trypsin
- Functional Word in a Protein. II. Repeating Words.:II. Repeating Words
- Functional Word in a Protein. I. Overlapping Words.:I. Overlapping Words
- A Simple Way to Identify Functional Sites in Protein. IV. Active Sites of Trypsin.:IV. Active Sites of Trypsin