Functional Word in Protein : VI. Recognition
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概要
- 論文の詳細を見る
Interaction between trypsin and its substrate, NDV-F, is investigated by two approaches, in which the natural sequence and the polar/non-polar sequence are used respectively. In the first approach that we call“stepwise recognition”, addition of the connector-Es of trypsin resulted in stronger interaction between trypsin and NDV-F than that reported previously.2) The polar sequence of trypsin could predict only a functional site near 84-D. In the second approach, however, when the cleavage site of NDV-F is added to the polar sequence of trypsin, the other active sites of trypsin, 40-H and 177-S, can be predicted. We call it“sudden recognition by chance encounters”. The results suggest that the function of trypsin is recognized only when the enzyme encounters its substrate by chance.
- 日本学士院の論文
著者
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KIHO Yukio
Ishihara Sangyo Kaisha, Ltd.
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BHANDARI Guru
Ricerca, Inc.
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UBASAWA Aiko
Woodward Laboratory
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PALMER Christopher
Ricerca, Inc.
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IKEDA Shigero
Emeritus Professor at Osaka University
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Ubasawa A
Woodward Lab. Yokohama Jpn
関連論文
- Basic construction of the functional system in a protein : I. Functional system of modified trypsin (m-trypsin)
- Functional Word in Protein : VI. Recognition
- Functional Word in a Protein : V. Comparative Linguistics
- Blobogical information transfer in a protein : II. Protein-protein interaction
- Biological information transfer in a protein : I. Closed circuit
- Basic construction of the functional system in a protein : III. Information transfer in a closed circuit
- Dynamic aspects of protein function : III. Comparison of homologous proteins isolated from various species
- Dynamic aspects of protein function : I. Rationale of mathematical approach
- Application of the Jellyfish Model : II. Higher Dimensional Structure of Trypsin
- Application of the Jellyfish Model : I. Virulency of Some Mammalian Viruses
- Basic construction of the functional system in a protein : II. Functional system of chymotrypsin
- Functional Word in a protein : IV. Alphabet
- Dynamic aspects of protein function : II. Metastable functional system of trypsin
- Functional Word in a Protein. III. Syntax and Energetics.:III. Syntax and Energetics
- A Simple Way to Identify Functional Sites in Protein III. Application of DEV Analysis to Proteins Other than Trypsin.:III. Application of DEV Analysis to Proteins Other than Trypsin
- Functional Word in a Protein. II. Repeating Words.:II. Repeating Words
- Functional Word in a Protein. I. Overlapping Words.:I. Overlapping Words
- A Simple Way to Identify Functional Sites in Protein. IV. Active Sites of Trypsin.:IV. Active Sites of Trypsin