Application of the Jellyfish Model : I. Virulency of Some Mammalian Viruses
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概要
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In contrast to natural sequence of trypsin, functional sites of polar sequence of trypsin can be predicted only in the presence of cleavage site (CL) of the substrate, surface protein-F of viruses having strong or intermediate virulencies (Jellyfish model). In the case of less-virulent viruses, however, things are not so simple as virulent ones and sometimes DEV model fails to predict the functional sites which are already assinged empirically by virologists as the cleavage site just upstream to the long span of hydrophobic amino acids in the natural sequence. Actually, there are lots of weak virulent viruses in nature. Simple mathematical calculation supports this possibility which suggests a limitation in the application of our models. Mutation and selection are considered to control these situations (Appendix).
- 日本学士院の論文
著者
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KIHO Yukio
Ishihara Sangyo Kaisha, Ltd.
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PALMER Christopher
Ishihara Sangyo Kaisha, Ltd.
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YAMADA Ryuichi
Ishihara Sangyo Kaisha, Ltd.
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OKABE Yasunori
University of Tokyo
関連論文
- Basic construction of the functional system in a protein : I. Functional system of modified trypsin (m-trypsin)
- Functional Word in Protein : VI. Recognition
- Functional Word in a Protein : V. Comparative Linguistics
- Blobogical information transfer in a protein : II. Protein-protein interaction
- Biological information transfer in a protein : I. Closed circuit
- Basic construction of the functional system in a protein : III. Information transfer in a closed circuit
- Dynamic aspects of protein function : III. Comparison of homologous proteins isolated from various species
- Dynamic aspects of protein function : I. Rationale of mathematical approach
- Application of the Jellyfish Model : II. Higher Dimensional Structure of Trypsin
- Application of the Jellyfish Model : I. Virulency of Some Mammalian Viruses
- Basic construction of the functional system in a protein : II. Functional system of chymotrypsin
- Functional Word in a protein : IV. Alphabet
- Dynamic aspects of protein function : II. Metastable functional system of trypsin
- Functional Word in a Protein. III. Syntax and Energetics.:III. Syntax and Energetics
- A Simple Way to Identify Functional Sites in Protein III. Application of DEV Analysis to Proteins Other than Trypsin.:III. Application of DEV Analysis to Proteins Other than Trypsin
- Functional Word in a Protein. II. Repeating Words.:II. Repeating Words
- Functional Word in a Protein. I. Overlapping Words.:I. Overlapping Words
- A Simple Way to Identify Functional Sites in Protein. IV. Active Sites of Trypsin.:IV. Active Sites of Trypsin