ACTHによる實驗的シヨックとその防止に關する研究

概要

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We once injected ACTH (manufactured by Organon Co.) intravenously for the purpose of Thorns test and met with serious shock symptomes and performed observations of various kinds, together with pathologic research about both experimental shock caused by ACTH and its prevention using guinea pigs. The results are as follows. 1) We succeeded in raising anaphylaxy shock experimentally using ACTH, and found characteristic changes of anaphylaxy histologically. 2) The degree of shock symptomes raised by ACTH of Organon Co. was much larger than that of Armour Co. in histologic changes, the former was more remarkable than the latter. 3) Changes were found histologically in central nervous cells. 4) Shock were prevented by chlorpromazine, but considerable changes were recognized immediately after the shock histologically. 5) About the prevention of shock using meprobamate, we are now in researching.
社団法人日本内科学会の論文