Unresectable Advanced Gastric Cancer Effectively Treated by Combined Chemo-Immunotherapy. A Report of Two Cases.
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概要
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We have experienced two cases of unresectable advanced gastric cancer effectively treated by chemo-Immunotherapy. One case was of a 68-year-old male patient diagnosed as having inoperable advanced gastric cancer with liver and lung metastasis. This patient was treated by combined chemo-immunotherapy of MMC 10mg/M, 5'-DFUR 800mg/day and OK-432 5 KE/2W. At 6 months later, a computed tomography (CT) scan and upper gastrointestinal (GI) series revealed that the metastatic liver tumors and stomach lesion were remarkably decreased in size, and endoscopic biopsy confirmed no cancer cells in the stomach lesion. Moreover, the metastatic lung tumor had disappeared on chest X-ray. The other case was of a 68-year-old female patient with unresectable advanced gastric cancer treated by combined administration of MMC 10mg/M, 5-FU 200mg/day and OK-432 5 KE/2W. At 2 months after commencing the treatment, there was a reduction in the serum carcinoembryonal antigen (CEA) level. At 6 months later, the CEA had decreased to normal, the primary and metastatic sites had completely disappeared on CT, and endoscopic biopsy confirmed no cancer cells in the stomach lesion. This patient has survived to date for 5 years and 6 months after commencing the treatment. These results suggested that combined chemo-immunotherapy of MMC, antimetabolite, and OK-432 was an effective treatment for unresectable advanced gastric cancer.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Shirouzu Kazuo
Department Of Surgery Kurume University
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Terasaki Yasuhiro
Department Of Pathology Nippon Medical School Tokyo And Brain Science Institute Riken
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TAKEDA JINRYO
Department of Surgery, Kurume University School of Medicine
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MURAKAMI NAOTAKA
Department of Surgery, Kurume University School of Medicine
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YAMASAKI YOSHIYA
Department of Surgery, Kurume University School of Medicine
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KOUFUJI KIKUO
Department of Surgery, Kurume University School of Medicine
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YANO SHOJIRO
Department of Gastroenterology and Surgery, Kurume University School of Medicine
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AOYAGI KEISHIRO
Department of Gastroenterology and Surgery, Kurume University School of Medicine
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KOUFUJI KIKUO
Department o f Surgery, Kurume University School of Medicine
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TAKEDA JINRYO
Department of Gastroenterology and Surgery, Kurume University School of Medicine
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