Immunohistochemical Study on the Expression of Cyclin D1 and E in Gastric Cancer.
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概要
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Cyclin D1 and E have been found to be deregulated and overexpressed in various types of cancers. In order to study the cell cycle regulatory mechanisms in gastric cancer, we have analyzed the protein expression of cyclin D1 and cyclin E in 76 tumor specimens from patients with primary gastric cancer, using immunohistochemistry. Overexpression of cyclin D1 was observed in 38 cases (50.0%). Overexpression of cyclin E was observed in 40 cases (52.6%). There was no significant difference between the expression of cyclin D1 and any clinicopathological factor. Cyclin E overexpression was correlated with a high incidence of lymph node metastasis, a low incidence of T1, and with Stage I. There was no significant difference in survival curves between cyclin D1 (+) and cyclin D1 (-). The survival curves of cyclin E (-) were significantly higher than those of cyclin E (+). These results suggested that in gastric carcinoma, cyclin E overexpression was useful as a prognostic indicator, but cyclin D1 was not.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Shirouzu Kazuo
Department Of Surgery Kurume University
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Tanaka Masaharu
Department Of Neuropsychiatry Mishima Hospital
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Terasaki Yasuhiro
Department Of Pathology Nippon Medical School Tokyo And Brain Science Institute Riken
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MURAKAMI NAOTAKA
Department of Surgery, Kurume University School of Medicine
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YAMASAKI YOSHIYA
Department of Surgery, Kurume University School of Medicine
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AOYAGI KEISHIRO
Department of Gastroenterology and Surgery, Kurume University School of Medicine
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KOUFUJI KIKUO
Department o f Surgery, Kurume University School of Medicine
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YANG SHOJIRO
Department of Surgery, Kurume University School of Medicine
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TAKEDA JINRYO
Department of Gastroenterology and Surgery, Kurume University School of Medicine
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TAKEDA JINRYO
Department o f Surgery, Kurume University School of Medicine
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SHIROUZU KAZUO
Department of Gastroenterology and Surgery, Kurume University School of Medicine
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