A case report of HBV carrier with seronegative for anti-HBc caused by vertical transmission.

概要

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A boy aged 2 was reported that anti-HBc had been negative in spite of HBV carrier caused by vertical transmission. No liver dysfunction was observed after birth. It was supporsed that HBV transmitted transplacentally in utero, because: 1) HBs antigen was positive within the first week of age. 2) HBV-DNA was positive in umbilical cord blood. Though the father showed normal response of anti-HBc after acute hepatitis B, the mother revealed low level of anti-HBc at the labor (62.7%, RIA) and 2 years after the labor (78.0%). Genetic abnormality might be suggested about the lack of anti-HBc in patient. On immunological examination, no abnormality was indicated for the mother but low titer of IgA and decrease of the population of OKT4 cell and OKT4/8 ratio were pointed out in the patient. This paper suggests the pathological role of anti-HBc in HBV infection, especially transplacental transmission in utero.
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