原発性胆汁性肝硬変 (PBC) における抗セントロメア抗体 (ACA) の臨床的意義

概要

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Serum anticentromere antibody (ACA) was measured in 123 cases of various chronic liver diseases and especially in primary biliary cirrhosis (PBC), the relationship between the positiveness of ACA and symptom, laboratory data, histology and clinical course was studied. Subjects were 123 cases of chronic liver disease, 25 cases of PBC, 11 cases of lupoid hepatitis and 87 cases of other chronic liver diseases (73 of viral and 14 of alcoholic). Prevalence of ACA was highest (44%) in patients with PBC compared with other chronic liver disease.<BR>In PBC patient, most ACA positive cases were asymptomatic and complicated with extra hepatic symptoms of CREST syndrome (82%) and showed low titer of antimitochondria antibody (AMA), low levels of serum IgM and bilirubin, gradually progressive clinical course, histologically mild changes, and prognosis was suspected good compared with ACA negative cases. Therefore, in ACA positive cases there might be a distinct of PBC different from that in ACA negative cases.
社団法人日本肝臓学会の論文