Effect of isosorbide dinitrate on portal hypertension of cirrhotic rat.
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The effects of isosorbide dinitrate (ISDN) on hepatic and systemic hemodynamics were investigated in thioacetamide induced cirrhotic rats. ISDN reduced portal pressure resulting from decreasing of portocollateral resistance. ISDN showed a significant reduction of portal pressure at the infusion rate of 1μg/kg bw/min and no significant change in the reduction of portal pressure even after increasing of ISDN dose. At the rate of 1μg/kg bw/min, ISDN had no effect on liver blood flow and peripheral artery pressure. At the rate of 100μg/kg bw/min, ISDN decreased liver blood flow as the result of increasing collateral blood flow. ISDN showed different effects between control and cirrhotic rats. ISDN reduced portal pressure in cirrhotic.
- 社団法人 日本肝臓学会の論文
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