インターフェロン治療中に種の不整脈を発生したC型慢性活動性肝炎の1例

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The patient was a 66-year-old male who had had hypertention since 1963. On December 1992, the diagnosis of chronic hepatitis (CAH2A) was made. Administration of interferon (IFN)α2b 10MU/day was commenced in December. The serum aminotransferase level normalized rapidly. However, eight weeks after the start of IFN therapy, the patient complained of palpitation. Electrocardiograph (ECG) showed arrythmias of rapid atrial fibrillation (Af) and paroxysmal supraventricular tachycardia. By the administration of anti-arrhythmia drugs the palpitation decreased markedly, and the IFN therapy was continued. Holter ECG after ceasing IFN therapy did not show the previously observed various arrhythmias such as paroxysmal Af, intensive occurrence of premature supraventricular contractions, sinus arrest or sinus bradycardia. In view of the clinical course, the arrhythmias were strongly suspected to be induced by IFN. Arrhythmia induced by IFN therapy for chronic hepatitis was very rare, but we showed concern about the side effect of arrhythmia on IFN therapy for chronic hepatitis.
社団法人日本肝臓学会の論文