Cytogenetic Study of 48 Patients with Multiple Myeloma and Related Disorders

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概要

• 論文の詳細を見る

• We studied 48 patients with multiple myeloma and its related disorders (plasma cell dyscrasias: PCD). Clonal changes were observed in 19 patients (39.6%), which included 9 untreated and 10 treated patients. Chromosomal gains of 3, 11 and loss of 13 were the most frequent numerical chromosome aberrations. Chromosome 13 was lost at an early stage and 17p (p53) abnormality appeared in an advanced stage of the disease. The most common additional region was lq which contained a locus of the IL-6 receptor gene instead of 7p, the locus of the IL-6 gene. The break points were clustered at 1p13, 6q21, 7p11.2 14q32, 17p11 and 19p13.3, which were the loci of protooncogenes, tumor suppresser genes or immunoglobulin-related genes. Three patients showed a balanced translocation of t (11; 14) (q13; q32). The characteristic features of chromosomal changes in PCD were frequent chromosomal gains and losses and rare balanced translocations. These findings are similar to those found in secondary leukemias and solid tumors, rather than de novo leukemias.

• 日本リンパ網内系学会の論文
• 2003-10-01

著者

• Kojima M

  Department Of Anatomic And Diagnostic Pathology Dokkyo University School Of Medicine

• Nimura Takashi

  Department Of Hematology Nephrology And Rheumatology Akita University Graduate School Of Medicine

• TAKAHASHI Naoto

  Third Department of Internal Medicine, Akita University School of Medicine

• HIROKAWA Makoto

  Third Department of Internal Medicine, Akita University School of Medicine

• SAWADA Ken-ichi

  Third Department of Internal Medicine, Akita University School of Medicine

• MIURA Ikuo

  Third Department of Internal Medicine, Akita University School of Medicine

• Miura I

  Department Of Hematology And Oncology St Marianne University School Of Medicine

• Miura Ikuo

  聖マリアンナ医科大学 血液･腫瘍内科

• Kagami Yoshitoyo

  東海大学 医学部血液･腫瘍内科

• Kagami Yoshitoyo

  名古屋大学医学部附属病院 病理部

• Kanakura Yuzuru

  大阪大学 医学系研究科心臓血管外科

• Kamiya Yoshikazu

  Department Of Hematology Meitetsu Hospital

• Kume M

  Department Of Hematology Sapporo Hokuyu Hospital

• KUME MASAAKI

  Third Department of Internal Medicine, Akita University School of Medicine

• MIURA Akira

  Akita University

• NIMURA Takashi

  Third Department of Internal Medicine, Akita University School of Medicine

• KOBAYASHI Yoshimi

  Third Department of Internal Medicine, Akita University School of Medicine

• YOSHIOKA Tomoko

  Third Department of Internal Medicine, Akita University School of Medicine

• MIURA Akira

  Third Department of Internal Medicine, Akita University School of Medicine

• Kasai M

  Department Of Anatomic And Diagnostic Pathology Dokkyo University School Of Medicine

• Kikuchi Masahiro

  福岡大学 医学部内科学第一

• Miura Akira

  Third Department Of Internal Medicine Akita University School Of Medicine

• Kume Masaaki

  Division Of Hematology And Oncology Department Of Medicine Akita University School Of Medicine

• Takahashi Naoto

  Department Of Hematology Nephrology And Rheumatology Akita University Graduate School Of Medicine

• Nimura Takashi

  Department Of Internal Medicine Senboku General Hospital

• Kobayashi Yukio

  Hematology And Stem Cell Transplantation Divisions National Cancer Center Hospital

• Takahashi Naoto

  Akita Univ. Graduate School Of Medicine Akita Jpn

• Matsuura A

  Department Of Gastroenterology Aichi Cancer Center Hospital

• Miura Ikuo

  Department Of Hematology And Oncology St Marianne University School Of Medicine

• Miura Ikuo

  Third Department Of Internal Medicine Akita University School Of Medicine

• Miura Ikuo

  Department Of Internal Medicine Iii Akita University School Of Medicine

• Kami Masahiro

  Division Of Hematology/oncology Kameda General Hospital

• Kodera Y

  Department Of Internal Medicine Japanese Red Cross Nagoya First Hospital

• Yoshioka Tomoko

  Division Of Hematology And Nephrology Department Of Internal Medicine Akita University School Of Med

• Yoshioka Tomomi

  Akita University School Of Medicine

• Sawada Ken-ichi

  秋田大学 医学研究科血液･腎臓･膠原病内科学

• Sawada Ken-ichi

  Third Department Of Internal Medicine Akita University School Of Medicine

• Yoshioka Toshiaki

  Department Of Surgery Akita University School Of Medicine

• Kobayashi Yoshimi

  Division Of Hematology And Oncology Department Of Medicine Akita University School Of Medicine

• Kojima Masaru

  First Department Of Pathology Dokkyo University School Of Medicine

• Kume Masaaki

  Third Department Of Internal Medicine Akita University School Of Medicine

• Miura A

  Third Department Of Internal Medicine Akita University School Of Medicine

• Kawabata Yoshinari

  Department Of Internal Medicine Iii Akita University School Of Medicine

• Tsuchiya Norihiko

  Department Of Urology Akita University Graduate School Of Medicine

• Kojima Masaru

  Department Of Anatomic And Diagnostic Pathology Dokkyo Medical University

• Hirokawa M.

  Department Of Hematology Nephrology And Rheumatology Akita University Graduate School Of Medicine

• Saito K

  Akita Univ. Graduate School Of Medicine Akita Jpn

• Kawabata Yoshinari

  Division Of Hematology And Nephrology Department Of Internal Medicine Akita University School Of Med

• Hirokawa Makoto

  Department Of Hematology Nephrology And Rheumatology Akita University Graduate School Of Medicine

• Kojima Masaru

  Department Of Anatomic Diagnostic Pathology Dokkyo University School Of Medicine

• Kimura Yoshizo

  Department Of Pathology School Of Medicine Kurume University

• Kobayashi Yoshimi

  Third Department Of Internal Medicine Akita University School Of Medicine

• Kojima Masaru

  Departments Of Pathology And Clinical Laboratories

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