Studies on high avidity anti-DNA antibody by using RECOMBIGEN anti DNA Hi-A Kit.

概要

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The usefulness of the new assay kit for high avidity anti-DNA antibody measurement, named RECOMBIGEN anti DNA Hi-A Kit (Hi-A Kit) was studied. The thirty three sera, whose titers of anti-DNA antibody were higher than 20U/ml by standard anti-DNA antibody assay, were measured by using Hi-A Kit. Confidence variation of intra-assay, interassay, inter-lot were good value. The titers of anti-DNA antibody by the new kit in 14 inactive systemic lupus erythematosus (SLE) were within normal range in 11 sera and were low in 3 sera. On the contrary the titers were high in all 15 active SLE sera. Non SLE patients (4 patients) indicated low titers. Hi-A Kit revealed good sensitivity and specificity for the active SLE. In conclusion, our data suggest this new kit is a useful tool for the diagnosis and clinical management of SLE.
日本臨床免疫学会の論文