無菌性脳脊髄膜炎を併発したシェーグレン症候群5症例の臨床的検討
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Clinical studies and typing for HLA-A, HLA-B, HLA-C and HLA-DR loci on five cases with Sjögren's syndrome with aseptic meningoencephalitis were performed. In our cases, four of the five patients had sicca syndrome alone without other connective tissue disease. Only one patient had Sjögren's syndrome with adult Still's disease Three of the five patients had clinical manifestation of Raynaud's phenomenon and non-deforming arthritis. Two of the five patients had renal tubular acidosis. Four of the five patients were subclinical Sjögren's syndrome. No HLA antigens specific for Sjögren's syndrome were found out in all patients. The CSF pressure was normal. There was mild to moderate pleocytosis in each case with mononuclear cell predominance. The CSF protein concentration was elevated in five of the eight episodes. The initial CSF: blood glucose ratios was low in four of the five episodes. Reccurent episodes of aseptic meningoencephalitis were documented in two of the four patients. Viral, fungal, and bacterial cultures were uniformly negative.The association of Sjögren's syndrome with aseptic meningoencephalitis is discussed.
- 日本臨床免疫学会の論文
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