Rat Ovarian 20.ALPHA.-Hydroxysteroid Dehydrogenase-1 May Belong to Aldo-Keto Reductase Superfamily.
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概要
- 論文の詳細を見る
We have previously purified the 20α-hydroxysteroid dehydrogenase (20α-HSD) molecule from normal mature rat ovarian cytosol [Biochim. Biophys. Acta, 1991, 1079: 112-118]. In order to further characterize the 20α-HSD and to obtain information for molecular cloning of the enzyme, we determined its N-terminal amino acid sequence. The sequence was shown to be Ser-Lys-lle-Gln-LysMet-Glu-Leu-Asn-Asp-Gly-His-Ser-Ile-Pro-Val-Leu-Gly-Phe-Xaa-Thr. A search of the SWISS-PROT protein sequence database for N-terminal amino acid sequence similarities revealed 6 highly homologous proteins, including bovine prostaglandin F synthase, rat liver 3α-hydroxysteroid dehydrogenase, bovine lens aldose reductase, human aldose reductase, frog ε-crystallin and human liver chlordecone reductase, suggesting that rat ovarian 20α-HSD belongs to the aldo-keto reductase gene superfamily.
- 日本繁殖生物学会の論文
著者
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Shiota Kunio
Laboratory Of Cellular Biochemistry Animal Resource Science/veterinary Medical Sciences Graduate Sch
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Ogawa Tomoya
Laboratory Of Cellular Biochemistry Animal Resource Science/veterinary Medical Science The Universit
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TAKAHASHI Michio
Neterinary Physiology, Veterinary Medical Science, The Uiversity of Tokyo
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Noda Ken
Laboratory of Cellular Biochemistry
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YAGI Shintaro
Neterinary Physiology, Veterinary Medical Science, The Uiversity of Tokyo
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SHIOTA Kunio
Laboratories of Cellular Biochemistry
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NODA Ken
Laboratories of Cellular Biochemistry
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