THE MOBILIZATION OF PLASMA LIPIDS BY HISTAMINE IN DOGS
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概要
- 論文の詳細を見る
The aim of the present work was to study the mechanism of the mobilization of plasma lipids produced by histamine in the dog, <I>in vivo</I>. The increase of plasma lipids by histamine <I>in vivo</I> was suppressed by cimetidine, but not by diphenhydramine. Although, histamine increased the level of plasma adrenaline, adrenaline does not appear to contribute to the lipolysis stimulated by histamine, because propranolol and alprenolol, β-adrenergic blocking agents, did not affect the lipolysis stimulated by histamine. From these data it is concluded that the increase of plasma lipids <I>in vivo</I> is not attributable to the release of adrenaline from adrenal glands by histamine, but is produced by the stimulation through H<SUB>2</SUB>-receptors in fat cells.
- 社団法人 日本薬理学会の論文
著者
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Tsuboi Minoru
Department Of Pharmacology Tokyo College Of Pharmacy
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Komabayashi Takao
Department Of Pharmacology Tokyo College Of Pharmacy
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SAKAMOTO Seiya
Department of Pharmacology, Tokyo College of Pharmacy
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KOMABAYASHI Takao
Department of Human System Science, Graduate School of Decision Science and Technology, Tokyo Institute of Technology
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