HYDROLYSIS OF ESTER-TYPE DRUGS BY THE PURIFIED ESTERASE FROM HUMAN INTESTINAL MUCOSA
スポンサーリンク
概要
- 論文の詳細を見る
Esterase from human intestinal mucosa was purified 210 fold by solubilization with Triton X-100, chromatography on DEAF-cellulose, Sephadex G-100 and hydroxylapatite, and isoelectric focusing. The purified esterase showed a single band by polyacrylamide gel electrophoresis. The molecular weight of the purified esterase was estimated to be about 55, 000 by gel filtration on Sephadex G-150, and the isoelectric point was 5.02. The purified esterase was strongly inhibited by diethyl p-nitrophenyl phosphate (E-600) and diisopropyl fluorophosphate (DFP), and was not inhibited by eserine sulfate and p-chloromercuribenzoate. The purified esterase from human intestinal mucosa was found to be one of the carboxylesterases. The purified esterase hydrolyzed ester-type drugs, i.e., aspirin, clofibrate, indanyl carbenicillin and procaine, but did not hydrolyze amide-type drugs and choline-type drugs.
- 社団法人 日本薬理学会の論文
著者
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MORIKAWA Masako
Department of Pharmaceutical, Tokyo University of Pharmacy and Life Science
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Yamada Takashi
Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima Uni
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INOUE Michiko
Department of Global Agricultural Sciences, Graduate School of Agricultural and Life Sciences, The U
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Inoue Michiko
Department Of Pharmacology Tokyo College Of Pharmacy
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SUGIURA MAMORU
Department of Pharmacy, Gifu College of Pharmacy
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Morikawa Masako
Department Of Pharmaceutical Tokyo University Of Pharmacy And Life Science
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Yamada Takashi
Department Of Chemistry Faculty Of Science And Engineering Konan University
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Sugiura Mamoru
Department Of Pharmacy Gifu College Of Pharmacy
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TSUBOI MINORU
Department of Pharmacology, Tokyo College of Pharmacy
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Tsuboi Minoru
Department Of Pharmacology Tokyo College Of Pharmacy
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Yamada Takashi
Department Of Animal Science Graduate School Of Agricultural Science Kobe University
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Morikawa Masako
Department Of Biochemistry The Nippon Dental University School Of Life Dentistry At Tokyo
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