Effect of FK973, a new antitumor antibiotic, on the cell cycle of L1210 cells in vitro.
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概要
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Our previous study showed that FK973 (11-acetyl-8-carbamoyloxymethyl-4-formyl-14-oxa-1, 11 diazatetracyclo [7.4.1.0<SUP>2, 7</SUP>0<SUP>10, 12</SUP>]tetradeca-2, 4, 6-trien-6, 9-diyl diacetate), a novel substituted dihydrobenzoxazine, which is a derivative of the fermentation product of <I>Streptomyces sandaensis</I> No. 6897, had strong antitumor effects on experimental tumors in vitro and in vivo. In this report, we investigated its effect on the cell cycle of murine leukemia L1210 cells in vitro by means of DNA/5-bromo-2'-deoxyuridine double staining and compared these effects with those of other antitumor drugs. Both FK973 and mitomycin C arrested the cells in the G<SUB>2</SUB> phase. Vinblastine arrested the cells in the M phase and cytosine arabinoside, in the G<SUB>1</SUB> phase. Although FK973 and mitomycin C were shown to act on the cell cycle in a similar way, FK973 was slower in producing its effect. From the results, FK973 arrests the cells in the G<SUB>2</SUB> phase, and it appears that FK973 must be converted into the activated form in the cells for the development of its antitumor effects.
- 公益社団法人 日本薬理学会の論文
著者
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Nakamura Takaaki
Department Of Anatomy Shiga University Of Medical Science
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Matsumoto Sanae
Department Of Anesthesiology Kansai Medical University
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Shimomura Kyoichi
Department Of Pharmacology Pharmacological Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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MANDA Toshitaka
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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MORI Jo
Department of Pharmacology, Product Development Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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NAKAMURA Takaaki
Department of Pharmacology, Product Development Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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MASUDA Kikuo
Department of Pharmacology, Product Development Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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OKU Toshiko
Department of Pharmacology, Product Development Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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