The Effect of Nilvadipine, a Dihydropyridine Type Calcium Channel Blocker, on Local Cerebral Blood Flow in Rats.
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概要
- 論文の詳細を見る
The effect of nilvadipine, a dihydropyridine type calcium channel blocker, on local cerebral blood flow (lCBF) was investigated using the autoradiographic iodo[<SUP>14</SUP>C]antipyrine technique in rats. In control rats, lCBF in cortical areas and in the superior colliculus and inferior colliculus was higher than that in the hippocampus, septal nucleus, globus pallidus and substantia nigra. Nilvadipine (32 μg/kg, i.v.) increased lCBF in all structures (significantly in 11 of 21 structures) in spite of a 33% reduction in mean arterial blood pressure. These results confirm that nilvadipine has the ability to increase cerebral blood flow.
- 公益社団法人 日本薬理学会の論文
著者
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SATOH Hisashi
Department of Biochemical Pharmacology, Faculty of Pharmaceutical Sciences University of Chiba
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MORI Jo
Department of Pharmacology, Product Development Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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Kohsaka Masanobu
Department of Pharmacology, Product Development Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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Kohsaka Masanobu
Department of Pharmacology, Pharmacological Research Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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Furuichi Yasuhisa
Department of Pharmacology, Product Development Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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Takakura Shoji
Department of Pharmacology, Product Development Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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