Nilvadipine, a New Calcium Channel Blocker, Reduces Ischemic Brain Injury in Rats.
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概要
- 論文の詳細を見る
The effects of nilvadipine, a dihydropyridine type calcium channel blocker, on cerebral infarction induced by focal brain ischemia was studied in rats. The area of infarction was measured 24 hr after occlusion of the middle cerebral artery (MCA) in spontaneously hypertensive rats using triphenyltetrazolium chloride. Nilvadipine, given immediately after MCA occlusion, reduced the area of infarction significantly at doses of 0.32 mg/kg (i.p.) and 3.2, 10 and 32 mg/kg (p.o.). Nicardipine suppressed the area of infarction at a dose of 32 mg/kg (p.o.). The results suggest that nilvadipine is effective against ischemic brain injury.
- 公益社団法人 日本薬理学会の論文
著者
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Handa Jyoji
Department Of Anatomy And Neurosurgery Shiga University Of Medical Science
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Shiino Akihiko
Department Of Neurosurgery Shiga University Of Medical Science
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SATOH Hisashi
Department of Biochemical Pharmacology, Faculty of Pharmaceutical Sciences University of Chiba
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MORI Jo
Department of Pharmacology, Product Development Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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Takakura Shoji
Department of Pharmacology, Product Development Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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Handa Jyoji
Department of Neurosurgery, Shiga University of Medical Sciences
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Susumu Teruo
Department of Pharmacology, Product Development Laboratories, Fujisawa Pharmaceutical Co., Ltd.
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- Nilvadipine, a New Calcium Channel Blocker, Reduces Ischemic Brain Injury in Rats.