口蓋裂の実験的発生(第1報) : Trypan Blue による

概要

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Trypan blue solution was injected subcutaneously to pregnant female mice and the palates of the embryos were examined on the 18th day of the pregnancy, in order to study the cleft palate induced by abnormal intrauterine environment.The results obtained were as follows: (1) In the first group, to which 0.2cc of 1% solution was administered on the 8th day of pregnancy, one case of cleft palate was observed. (2) In the second group, to which 0.2cc of 5% solution was administered daily on the 6th and 7th day of gestation, one embryo with celeft palate was observed. (3) In the control group, to which physiological saline solution was given, no cleft palate was observed. (4) In the treated groups, the incidence of intrauterine death and resorption of the embryos was high.It was found that there was a correlation between the incidence and the amount of the dye.It may be concluded that cleft palate as phenacopies is induced by trypan blue injection.