騒音刺戟による先天性崎型発現に関する実験的研究

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It has been thought that noise may be stressor, and stress in early stage of pregnancy is.considered as one of the etiologic factors of malformations at present. This experiment was performed in order to study the effect of noise given to female pregnant mice on their offsprings.White noise was given pregnant female mice of ddN strain, for 6 hours daily from the 11th day to 14th day of pregnancy, and the embryos were examined on the 18th day.The results obtained were as follows :(1) In the treated group, in which the noise of 90 phon was given, and in the control group, no malformations were observed. In the treated group, in which the noise of 100phon was given, one case of polydactylia was observed. And in the group, in which the noise of 110phon was given, 7 cases of malformation were observed. They were one case of cleft palate, one polydactylia, four encephalocele and one encephalocele with cleft face.Therefore, it became clear that noise induced malformations.(2) Even by the noise of 90 phon, the weight of embryos was decreased, and the louder noise, was given the more it was decreased.(3) Calculating blood eosinophils as stress index before and after noise stimulation, the louder noise was given the more eosinophils were decreased. While eosinophils were not so much -decreased still by 90 phon, they were decreased remarkably by the noise of 100phon.Therefore, it was found that noise stimulation played a role as stressor.It was infered as to teratogenic activity of noise that maternal pituitary-adrenocortical system responded to noise and affected embryos. Since teratogenic activity, growth inhibiting effect and decreasing effect against eosinophils of noise have been just found in mice, some undesirable influence upon embryos may appear also in humans if women are subjected to noise stimulation in early stage of pregnancy.

著者

横堀国器
群馬大学医学部耳鼻咽喉科学教室

騒音刺戟による先天性崎型発現に関する実験的研究

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