顔面神経麻痺と水痘帯状疱疹ウイルス(第1報) : 血清抗体価,および皮内反応について

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A correlation between peripheral facial paralysis and varicella-zoster virus (VZV) was discussed. The level of anti-VZV antibody in the serum was measured in 155 patients; consisting of 33 patients of Ramsay-Hunt syndrome, 105 of Bells palsy, 6 of recurrent facial paralysis, 8 of otitic palsy and 3 others, and in 61 patients with inflammation in ENT regions as a control group.In antibody assay to VZV, 4 methods of complement fixation (CF), neutralization (NT), fluorescent antibody (FA) and immune adherence hemagglutination (IAHA) test were compared in sensitivity.VZV skin test, which seems to associate with cell mediated immunity (CMI), was also performed in these paralized and control patients.The results were as follows;1) Twenty-one cases (20%) of 105 Bells palsy seemed to be related with VZV reactivation, because of a significant rise and/or higher titers. These cases were considered as zoster sine herpete (Bell(V+)).2) Generally, cases of Ramsay-Hunt syndrome had a higher antibody titer of VZV than cases of Bell(V+). The titer of CF test showed a lower level than NT, FA and IAHA.3) CF test was the lowest in sensitivity and the antibody titers by NT, FA and IAHA test were roughly comparable.4) The severer was the paralysis, the higher was the level of VZV antibody.5) Positive rate of VZV skin test in Ramsay-Hunt syndrome and Bell(V+) was significantly lower as compared with that in otitic palsy and the control group.6) VZV skin test was more depressed in severe cases than in mild cases, and it tended to change to positive gradually during the follow-up.7) It may be possible to use the skin test for the judgement whether steroid therapy is suitable or not.
社団法人日本耳鼻咽喉科学会の論文

顔面神経麻痺と水痘帯状疱疹ウイルス(第1報) : 血清抗体価,および皮内反応について

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