Clinical Significance of TGF-.BETA.1 Expression in Evaluation of the Malignancy of Colorectal Cancer

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Purpose : In this study, transforming growth factor-β1 (TGFβ31), which has attracted attention as a growth factor of malignant tumor in recent years, was analyzed immunohistologically and serologically in patients having operation for colorectal cancer, and its clinical significance as a malignancy factor was examined.<BR>Subjects and Methods : On 72 patients who underwent operation for colorectal cancer in this department, immunohistological staining was performed using anti-TGF-β1 antibody. Serum TGF-β1 level was measured in these cases together with 25 non-cancer cases, a total of 97 cases. Results : In immunohistological staining, the positive rate became higher in lymph-node metastases and in progressing invasion into the vascular system. In serological examination, a significant difference was found between cancer cases and non-cancer cases, and TGF-β1 level rose with progressing liver metastasis and venous invasion.<BR>Conclusion : In colorectal cancer, TGF-β1 seemed to be usable for predictive evaluation of malignancies such as hematogenous metastasis preoperatively.
日本大腸肛門病学会の論文