Structural analysis of hollow fiber dialysis membranes for clinical use.

概要

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Little is known of the structure of hollow-fiber dialysis membranes for clinical use or of the effects of structure on solute and pure water permeability. Knowledge of such aspects of membrane structure as pore radius, surface porosity, tortuosity and water content is required if the desired membranes are to be designed. The objective of the present study, therefore, is to obtain data on the pore radius, surface porosity and tortuosity of hollow-fiber dialysis membranes through an analysis of measured water content, and of solute and pure water permeability on the basis of a newly introduced tortuous pore model. In regenerated cellulose membranes, pore radius ranges from 21 to 34 × 10-10 m, and huge pores ranging in radius from 47 to 64 × 10-10 m are identified for EVA membranes which are permeable to small amounts of serum protein. Values for surface porosity of the regenerated cellulose and EVA membranes are approximately 33 and 22%, and tortuosity is approximately 1.9 and 2.2, respectively. The tortuous pore model combined with the Lp and Pm method is well suited for elucidating the relationship between membrane structure and solute and pure water permeability.
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