Filtration characteristics of membranes for plasma separation and changes in membrane structure after blood contact.
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概要
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Plasma separation experiments with a hollow fibrous filter were made to clarify the effects of hematocrit, protein concentration and wall shear rate on filtrate flux. The resistance of the polarization layer caused by red blood cells is the dominant factor in filtration and accounts for 50 to 80% of total filtration resistance. Factors governing the filtrate flux in plasma separation are plasma viscosity, hematocrit and wall shear rate. An estimation equation for filtrate flux is proposed. Membrane structural changes after plasma separation were evaluated to clarify fouling characteristics in plasma separation by using radioisotope-labeled solute and scanning electron microscopy. The decrease in pore diameter and surface porosity is attributed to both protein adsorption onto pore walls and plugging by red blood cells.
- 公益社団法人 化学工学会の論文
著者
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SAKAI KIYOTAKA
Department of Applied Chemistry, Faculty of Science and Engineering, Waseda University
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OZAWA KIKUO
Department of Chemical Engineering, Waseda University
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MIMURA RISHICHI
Department of Chemical Engineering, Waseda University
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