A Trial of New Classification of Tumor Size in Colorectal Cancer.

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Eight hundred and forty-nine colorectal cancer patients, who received tumor resection in our hospital from 1978 to 1991, were examined. The maximum diameter of the tumor was classified into three groups: ‹30mm (group S), 30-80mm (group M), ›=80mm (group L).<BR>Group S accounts for 12 % of all patients, group M 74 %, group L 14 %. Pathological features such as degree of circumferential involvement, invasive shape of tumor, depth of invasion, pathological stage got worse according to tumor size. Liver metastasis, vessel invasion and histological type (wel. mod. por.) were better in group S than group M and L. Peritoneal dissemination and distant metastasis were worse in group L than group S and M. The same was the rate of curative resection, namely, group L showed apparently the worse rate (49 %), whereas group M showed 71 % and group S 91 % (P<0.0001). As tumor size became greater, cumulative 5 year survival rate got worse (S 76 %, M 52 %, L 41 %: P<0.0001). When the tumor was resected curatively, the rates of 5 year survival were almost the same among all groups (S 80 %, M 70 %, L 68 %). However, positive cancer cell infiltration on the surgical margin, as a factor by which patients were succumbed to palliation, was the most frequent in group L. Group S revealed the lowest ratio of tumor recurrence after curative resection (S 6 %, M 22 %, L 15 % : P<0.001).<BR>In conclusion, the new classification of tumor size seemed to be useful for preoperative prediction of postoperative prognosis.
日本大腸肛門病学会の論文

A Trial of New Classification of Tumor Size in Colorectal Cancer.

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