A Study on the Clinical Significance of Lymphatic Tissue Responses Against Rectal Cancer.

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One hundred and sixty-eight patients who underwent curative resection of rectal adenocarcinoma from 1981 to 1988 were studied to evaluate the clinical significance of the responses of lymphatic tissue against cancer. Lymphatic tissue was divided into four zones according to the distance from tumor : ‹zone 1 › invasive front of cancer, ‹zone 2 › peri-tumor area shortly outer from zone 1, ‹zone 3 › non-involved n 1 lymphnodes, ‹zone 4 › non-involved n 2 and n 3 lymphnodes.Histologic responses were evaluated in each zone lymphocyte infiltration (LI) in zone 1, lymphocytic follicle (LF) in zone 2, and paracor-tical hyperplasia (PH), germinal center hyperplasia (GH) and sinus histiocytosis (SH) in zone 3 and 4.<BR>The patients with high grade response of LI showed a significantly better survival curve compared to those with low grade one. The same was also seen in LF. Patients with high grade response of PH, GH or SH showed better survival curves than those with low grade response, respectively. The patients with 2 or 3 high grade responses among three factors in zone 3 or 4 showed a significantly better survival curve compared to those with only one high grade response or none.<BR>Multivariate analysis revealed that histologic responses in non-involved regional lymph nodes and lymphatic follicle were important prognostic factors.<BR>These results suggest that histologic investigation of the response of lymphatic tissue is useful to predict postoperative long-term prognosis of the rectal cancer patients.
日本大腸肛門病学会の論文

A Study on the Clinical Significance of Lymphatic Tissue Responses Against Rectal Cancer.

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