The Metabolic Mechanism of Cerebral Blood Flow Autoregulation in Dogs
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The effects of lowered perfusion pressure on the cerebral circulation, and on the lactate and acid-base parameter in cerebrospinal fluid (CSF) were studied in the light-anesthetized dogs. The cerebral perfusion pressure was lowered by bleeding the animal at the controlled arterial PCO2. There was a progressive increase in cisternal CSF lactate with consequent decrease in CSF pH and bicarbonate when perfusion pressure was reduced even though cerebral blood flow was unchanged. It is concluded that cerebral autoregulation in response to reduced perfusion pressure appears to be a function of tissue lactic acidosis, signifying tissue hypoxia due to the lowering of local cortical blood flow.
- International Heart Journal刊行会の論文
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