DECREASE IN ENDOTHELIUM DEPENDENT HYPOTENSION IN SPONTANEOUSLY HYPERTENSIVE RATS
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概要
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Endothelium-dependent and independent hypotension, vasodilation and relaxation were examined comparatively, in vivo and in vitro, in spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto rats (WKY). In conscious and unrestrained animals, the dose-dependent hypotensive responses to both acetylcholine and adenosine triphosphate (ATP) were attenuated in SHR, compared to findings in the WKY, while sodium nitroprusside lowered mean arterial pressure (MAP), to a similar degree in SHR and WKY. Acetylcholine, ATP and nitroprusside increased the heart rate of SHR and WKY, in a dose-related manner. Mesenteric and femoral blood flow was altered by acetylcholine, ATP and nitroprusside, in a similar manner in the SHR and WKY anesthetized with urethane. However, an ATP-induced reduction in renal blood flow was greater in the SHR than in the WKY. Acetylcholine and nitroprusside led to a concentration-dependent relaxation in the isolated mesenteric artery, to a similar extent in both strains of rats. The relaxation response to acetylcholine was nearly abolished by mechanical removal of the endothelium, but the nitroprusside-induced relaxation was not altered by this denudation. ATP did not influence contraction of the mesentric artery but did produce endothelium-dependent relaxation of aorta, in a dose-dependent manner. All these events suggest that suppression of the endothelium dependent relaxation of resistant arterioles relates to the maintenance of hypertension, in the SHR.
- 社団法人日本循環器学会の論文
- 1990-02-20
著者
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Kamide Kei
国立循環器病センター 高血圧腎臓内科
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Fujishima Masatoshi
Translational Research Center Kyoto University Hospital
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Fujishima Masatoshi
The Department Of Medicine And Clinical Science Graduate School Of Medical Sciences Kyushu Universit
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FUJISHIMA Masatoshi
Second Department of Internal Medicine, Faculty of Medicine, Kyushu University
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Takata Yutaka
Second Department Of Internal Medicine Faculty Of Medicine Kyushu University
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Takata Yutaka
Department Of Internal Medicine Kyushu Dental College
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Kobayashi Kazuo
Second Department of Internal Medicine
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TAKISHITA SHUICHI
Second Department of Internal Medicine, Faculty of Medicine, Kyushu University
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Fujishima Masatoshi
Second Department Of Internal Medicine Faculty Of Medicine Kushu University
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KOGA TOKUSHI
Second Department of Internal Medicine, Faculty of Medicine, Kyushu University
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Kamide Kei
St. Marianna University School Of Medicine
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Koga Tokushi
Second Department Of Internal Medicine Faculty Of Medicine Kyushu University
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Takishita Shuichi
Second Department Of Internal Medicine Sapporo Medical University School Of Medicine
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Fujishima Masatoshi
Medicine And Clinical Science. Graduate School Of Medical Sciences Kyushu University
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TAKISHITA Shuichi
Second Department of Internal Mecicine, Faculty of Medicine, Kyushu University
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Fujishima Masatoshi
Second Departemnt of Internal Medicine, Kyushu University
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