Central and Peripheral Mechanisms of the Enhanced Hypertension Following Long-term Salt Loading in Spontaneously Hypertensive Rats : THE 17th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
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概要
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We evaluated whether or not increased sodium (Na) concentrations of cerebrospinal fluid (CSF) and stimulated activities of brain renin-angiotensin system (RAS) contribute to an enhanced hypertension by salt overload in spontaneously hypertensive rats (SHR). Long-term salt loading (1% NaCl solution as drinking fluid) accelerated the development of hypertension in SHR, but did not alter the blood pressure (BP) in normotensive Wistar-Kyoto rats (WKY). CSF Na concentration was elevated in uninephrectomized (Nx) group as compared to that in control SHR, while in WKY CSF Na was not influenced by the treatment. A fall in BP by intravenous AVP antagonist or hexamethonium was greater in salt-loaded SHR than in controls. This hypotensive response to the combined blockade of AVP and SNS correlated with CSF Na in SHR but not in WKY. Plasma concentration of AVP and epinephrine tended to increase in relation to the degree of salt loading in SHR but not in WKY. Pressor responses to intracerebroventricular (ICV) angiotensin II (AII) and NaCl were greater in SHR than in WKY, although these responses were not influenced by chronic salt load in either SHR or WKY. The enhanced hypertensive action of ICV NaCl in SHR was abolished by pretreatment with ICV AII antagonist. Chronic saline drinking enhanced the depressor effect of ICV captopril in SHR but not in WKY. These observations suggest that salt overload in SHR may cause an elevated CSF Na concentration and an enhanced activity of brain RAS, which may increase activity of SNS and release of AVP, resulting in an enhanced development of hypertension.
- 社団法人日本循環器学会の論文
- 1988-11-20
著者
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Tsuchihashi Takuya
Department Of Internal Medicine Kyushu Dental College
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Fujishima Masatoshi
Translational Research Center Kyoto University Hospital
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Fujishima Masatoshi
The Department Of Medicine And Clinical Science Graduate School Of Medical Sciences Kyushu Universit
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FUJISHIMA Masatoshi
Second Department of Internal Medicine, Faculty of Medicine, Kyushu University
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Takata Yutaka
Second Department Of Internal Medicine Faculty Of Medicine Kyushu University
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Takata Yutaka
Department Of Internal Medicine Kyushu Dental College
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Tomita Yuji
Second Department Of Internal Medicine Faculty Of Medicine Kyushu University
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Tomita Y
Kyushu Inst. Technology Kitakyushu Jpn
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TSUCHIHASHI TAKUYA
Second Department of Internal Medicine, Faculty of Medicine, Kyushu University
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TAKISHITA SHUICHI
Second Department of Internal Medicine, Faculty of Medicine, Kyushu University
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KIMURA YORIO
Second Department of Internal Medicine, Faculty of Medicine, Kyushu University
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YAMASHITA YOSHIAKI
Second Department of Internal Medicine, Faculty of Medicine, Kyushu University
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Fujishima Masatoshi
Second Department Of Internal Medicine Faculty Of Medicine Kushu University
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KOGA TOKUSHI
Second Department of Internal Medicine, Faculty of Medicine, Kyushu University
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Kimura Yorio
Third Department Of Internal Medicine University Of The Ryukyus School Of Medicine
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Koga Tokushi
Second Department Of Internal Medicine Faculty Of Medicine Kyushu University
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Yazaki Yoshio
The Third Dept. Of Medicine University Of Tokyo
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Takishita Shuichi
Second Department Of Internal Medicine Sapporo Medical University School Of Medicine
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Yamashita Yoshiaki
Second Department Of Internal Medicine Faculty Of Medicine Kyushu University
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Fujishima Masatoshi
Medicine And Clinical Science. Graduate School Of Medical Sciences Kyushu University
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TAKISHITA Shuichi
Second Department of Internal Mecicine, Faculty of Medicine, Kyushu University
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Fujishima Masatoshi
Second Departemnt of Internal Medicine, Kyushu University
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