SUPPRESSION OF THE RENIN-ANGIOTENSIN SYSTEM INDUCED BY STREPTOZOTOCIN TREATMENT IN NEONATAL SPONTANEOUSLY HYPERTENSIVE RATS

スポンサーリンク

概要

• 論文の詳細を見る

• We studied whether or not neonatal streptozotocin (STZ) treatment would alter mean arterial pressure (MAP) and blood pressure regulating factors in conscious and unrestrained spontaneously hypertensive rats (SHR). Neonatal STZ administration to SHR resulted in type 2 diabetes mellitus with reduced MAP and heart rate. Plasma glucose was markedly increased in these diabetic animals and was inversely correlated with MAP. In the diabetic SHR, the hypotensive responses to captopril (SQ) or enalapril, administered intravenously, were diminished, regardless of preceding administrations of vasopressin V_1-antagonist (AVPA) or hexamethonium (C_6), when compared to findings in control rats. In contrast, the C_6-induced hypotension was similar in rats with diabetes and control animals. AVPA led to no decrease in MAP in either group. Hypotensive responses to SQ following AVPA and C_6 inversely correlated with the plasma levels of glucose in the diabetic group. The combined blockade of the renin-angiotensin system (RAS), sympathetic nervous system and vasoconstrictive action of vasopressin (AVP) abolished the differences in MAP between the groups. Pressor and bradycardic responses to intravenous noradrenaline, angiotensin II and AVP were practically identical in the diabetic and control SHR. Urinary aldosterone excretion rate was not altered by neonatal STZ treatment. In conclusion, a decrease in MAP in SHR with neonatal STZ treatment may be attributed to the suppressed pressor activity of RAS.

• 社団法人日本循環器学会の論文
• 1990-02-20

著者

• Tsuchihashi Takuya

  Department Of Internal Medicine Kyushu Dental College

• Fujishima Masatoshi

  Translational Research Center Kyoto University Hospital

• Fujishima Masatoshi

  The Department Of Medicine And Clinical Science Graduate School Of Medical Sciences Kyushu Universit

• FUJISHIMA Masatoshi

  Second Department of Internal Medicine, Faculty of Medicine, Kyushu University

• Takata Yutaka

  Second Department Of Internal Medicine Faculty Of Medicine Kyushu University

• Takata Yutaka

  Department Of Internal Medicine Kyushu Dental College

• Tomita Yuji

  Second Department Of Internal Medicine Faculty Of Medicine Kyushu University

• Tomita Y

  Kyushu Inst. Technology Kitakyushu Jpn

• Sadoshima Seizo

  Second Department Of Internal Medicine Faculty Of Medicine Kyushu University

• TSUCHIHASHI TAKUYA

  Second Department of Internal Medicine, Faculty of Medicine, Kyushu University

• NAKAO YAE

  Second Department of Internal Medicine, Faculty of Medicine, Kyushu University

• YAMASHITA YOSHIAKI

  Second Department of Internal Medicine, Faculty of Medicine, Kyushu University

• TAKISHITA SHUICHHI

  Second Department of Internal Medicine, Faculty of Medicine, Kyushu University

• IWASE MASANORI

  Second Department of Internal Medicine, Faculty of Medicine, Kyushu University

• Fujishima Masatoshi

  Second Department Of Internal Medicine Faculty Of Medicine Kushu University

• Nakao Yae

  Second Department Of Internal Medicine Faculty Of Medicine Kyushu University

• Iwase Masanori

  Second Department Of Internal Medicine Faculty Of Medicine Kyushu University

• Yazaki Yoshio

  The Third Dept. Of Medicine University Of Tokyo

• Yamashita Yoshiaki

  Second Department Of Internal Medicine Faculty Of Medicine Kyushu University

• Fujishima Masatoshi

  Medicine And Clinical Science. Graduate School Of Medical Sciences Kyushu University

• Fujishima Masatoshi

  Second Departemnt of Internal Medicine, Kyushu University

関連論文

• Association of the Functional Variant in the 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Gene With Low-Density Lipoprotein-Cholesterol in Japanese
• Loss of ACE2 accelerates time-dependent glomerular and tubulointerstitial damage in streptozotocin-induced diabetic mice
• The Japanese Society of Hypertension Committee for Guidelines for the Management of Hypertension
• Accumulation of common polymorphisms is associated with development of hypertension : a 12-year follow-up from the Ohasama study
• Association of SLC6A9 Gene Variants with Human Essential Hypertension
• Asymptomatic Cerebral Microbleeds Seen in Healthy Subjects Have a Strong Association With Asymptomatic Lacunar Infarction(Stroke)
• PJ-713 Seasonal Mortality Variation in Out-of-hospital Cardiac Arrest : Analysis from AMI-Kyoto Multi-Center Risk Study Database(PJ120,Cardiopulmonary and Critical Care/ACLS (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese
• OJ-058 Bone Marrow AT1 Receptor Augments Neointima Formation by Promoting Mobilization of Smooth Muscle Progenitor Cells in a Platelet-Derived SDF-1α-Dependent Manner(OJ10,Atherosclerosis, Basic (IHD),Oral Presentation (Japanese),The 73rd Annual Scientifi
• OE-232 Bone Marrow Angiotensin AT1 Receptor Regulates Differentiation of Monocyte/Macrophage-Lineage Progenitors from Hematopoietic Stem Cells(OE40,Atherosclerosis, Basic 2 (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japane
• FRS-066 When and How should We Use Central BP in Clinical Hypertension? : Report from ABC-J Study(FRS14,New Aspects for Hypertension (H),Featured Research Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• PJ-616 Mild Renal Dysfunction Accelerated Atherosclerotic Development by Augmenting Mobilization of Bone Marrow Monocyte-lineage progenitors from Bone Marrow via CCR2-Mediated Signals(Atherosclerosis, basic(08)(IHD),Poster Session(Japanese),The 72nd Annua
• PJ-376 Bone Marrow AT1 and AT2 Differentially Modulate Vascular Repair by Regulating Mobilization of Bone Marrow-derived c-Kit^-Sca-1^+Lin^- Progenitors via SDF-1 α/CXCR4 Axis(Restenosis basic/clinical(04)(IHD),Poster Session(Japanese),The 72nd Annual Sci
• OE-416 Novel Action of Angiotensin AT1 Receptor on Bone Marrow Stem Cells, Promotion of Monocyte/Macrophage Lineage Differentiation from Hematopoietic Stem Cells.(Atherosclerosis, clinical(02)(IHD),Oral Presentation(English),The 72nd Annual Scientific Mee
• OE-145 Multi-center Cross-sectional Study to Characterize Antihypertensive Treatments in terms of Central Blood Pressure Evaluated by Radial Artery Pulse Waveform(Hypertension, clinical(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting
• Clinical Practice Guidebook for Diagnosis and Treatment of Chronic Kidney Disease
• Possibility of Total Hip Arthroplasty Using Shape Memory Alloy
• Report of the Asian Forum of Chronic Kidney Disease Initiative (AFCKDI) 2007. "Current status and perspective of CKD in Asia" : diversity and specificity among Asian countries
• Abnormal nocturnal blood pressure profile is associated with mild cognitive impairment in the elderly : the J-SHIPP study
• Serum Gamma-Glutamyl Transferase Levels are Associated with Metabolic Syndrome in Community-Dwelling Individuals
• Association of monocyte chemoattractant protein 1 gene polymorphism with susceptibility to nonfamilial idiopathic dilated cardiomyopathy
• Alcohol Consumption Is Associated with Decreased Insulin Resistance Independent of Body Mass Index in Japanese Community-Dwelling Men
• Silent cerebral microbleeds associated with arterial stiffness in an apparently healthy subject
• FRS-068 Class Differences in the Effects of BP-lowering Drugs on Central Blood Pressure : The J-SHIPP Study(FRS14,New Aspects for Hypertension (H),Featured Research Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
• High Prevalence of Prehypertension Is Associated with the Increased Body Mass Index in Community-Dwelling Japanese
• Association between Serum Gamma-Glutamyl Transferase Level and Prehypertension among Community-Dwelling Men
• An Association between Body Mass Index and Estimated Glomerular Filtration Rate
• Effects of Obesity and Smoking on Mental Stress-Induced Blood Pressure and Augmentation Index Responses in Normotensive Young Males : The J-SHIPP Study
• PJ-431 Silent cerebral microbleeds : prevalence and associations with carotid arterial parameters in comparison with lacunar infarction and leukoaraiosis(Cerebrovascular circulation/Stroke(02)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting
• Guidelines for Diagnosis and Treatment of Patients With Vasospastic Angina (Coronary Spastic Angina) (JCS 2008) : Digest Version
• OJ-014 Spotty Calcification Pattern of Culprit Coronary Artery Plaque is Associated with Lipid-rich Characteristics on IB-IVUS(OJ03,Intravascular Imagings (I),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Soci
• Comparison of Arterial Functional Evaluations as a Predictor of Cardiovascular Events in Hypertensive Patients : The Non-Invasive Atherosclerotic Evaluation in Hypertension (NOAH) Study
• PE-121 Assessment of Relationship Between Calcification Pattern and Plaque Characteristics in Patients With Acute Coronary Syndrome : On Behalf of ATHLETE Investigators(Acute coronary syndrome, basic/clinical(03)(IHD),Poster Session(English),The 72nd Annu
• Candesartan Antihypertensive Survival Evaluation in Japan (CASE-J) Trial of Cardiovascular Events in High-Risk Hypertensive Patients : Rationale, Design, and Methods
• Improvement of Blood Pressure Control in Hypertensive Patients with Renal Diseases
• Angiotensin I converting enzyme inhibitor and worsening of anemia in hemodialysis patients:Prevention with rHuEPO
• Hypercholesterolemia and the Progression of the Renal Dysfunction in Chronic Renal Failure Patients
• Thyroid neoplasia and familial adenomatous polyposis/Gardner's syndrome
• Methicillin-Resistant Staphylococcus Aureus (MRSA) Isolation from pharyngeal Swab Cultures of Japanese Elderly at Admission to a Geriatric Hospital
• Effects of Intra-Arterial Infusion of Insulin on Forearm Vasoreactivity in Hypertensive Humans
• 1117 TRENDS IN INCIDENCE AND CASE-FATALITY OF CARDIOVASCULAR DISEASE IN A JAPANESE COMMUNITY : THE HISAYAMA STUDY
• Blood Pressure Control in Hypertensive Patients With a History of Stroke
• Voltage-Dependent Ca^ Channels in Resistance Arteries from Dahl Salt-Sensitive Rats
• Ultrasonographic Assessment of Regional Differenes in Atehrosclerotic Lesions in Patients with Hypertension, Diabetes Mellitus, or Both
• Discriminationg Factors for Recurrent Hypertension in Patients with Primary Aldosteronism after Adrenalectomy
• Difference in the Incidence of Cough Induced by Angiotensin Converting Enzyme Inhibitors: a Comparative Study Using Imidapril Hydrochloride and Enalapril Maleate
• Tolerability and Safety of a Calcium Channel Blocker in Comparison with a Diuretic in the Treatment of Elderly Ptients with Hypertension : Secondary Analysis of the NICS-EH
• EFFECT OF SINGLE-ADMINISTRATION CAPTOPRIL ON PLASMA AND URINARY VASOPRESSIN IN NORMOTENSIVE SUBJECTS AND PATIENTS WITH ESSENTIAL HYPERTENSION AND PRIMARY ALDOSTERONISM
• Central Cardiovascular Action of Urotensin II in Spontaneously Hypertensive Rats
• Central human cocaine- and amphetamine-regulated trasncript peptide increases arterial pressure in conscious rabbits
• Altered Diurnal Variation of Blood Pressure in Elderly Subjects with Decreased Activity of Daily Living and Impaired Cognitive Function
• Trends in the Pathophysiological Characteristics of Malignant Hypertension
• The Influence of Chronic Antihypertensive Treatment on the Central Pressor Response in SHR
• Cardiovascular Responses to Glutamate and Angiotensin II in Ventrolateral Medulla of Hypertension Induced by Chronic Inhibition of Nitric Oxide
• Prediction of the clinical and histological severity of IgA nephropathy by flow cytometry of urinary mononuclear cells
• Incidence of Methicillin-Resistant Staphylococcus Aureus (MRSA) Isolation in a Skilled Nursing Home : A Third Report on the Risk Factors for the Occurrence of MRSA Infection in the Elderly
• A Case of Primary Aldosteronism Associated with Renal Artery Stenosis and Preclinical Cushing's Syndrome
• Blood Pressure Response during Dental Surgery
• -0143-THE INFLUENCE OF DRINKING AND SMOKNG ON BLOOD PRESSURE "A 6-YEAR FOLLOW-UP STUDY"
• -0142-THE IMPACT OF BLOOD PRESSURE CHANGE ON HEART AND KIDNEY "A 6-YEAR FOLLOW-STUDY"
• SUPPRESSION OF THE RENIN-ANGIOTENSIN SYSTEM INDUCED BY STREPTOZOTOCIN TREATMENT IN NEONATAL SPONTANEOUSLY HYPERTENSIVE RATS
• SUPPRESSED SYMPATHETIC FUNCTION IN WISTAR RATS BRED SUCCESSIVELY ON LOW SALT DIET : Hypertension (II) : FREE COMMUNICATIONS (II) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• Transcranial Doppler Sonography and Ambulatory Blood Pressure Monitoring in Patients with Hypertension
• DOXAZOSIN AND 48-HOUR AMBULATORY BLOOD PRESSURE MONITORING IN NORMOTENSIVE SUBJECTS
• A Genome-Wide Association Study of Hypertension-Related Phenotypes in a Japanese Population
• Solitary Pontine Tuberculoma
• Ischemic Brain Metabolism in Patients With Chronic Cerebrovascular Disease : Increased Oxygen Extraction Fraction and Cerebrospinal Fluid Lactate
• Left Ventricular Mass Predicted by a Single Reading of Ambulatory Blood Pressure in Essential Hypertension
• Mechanism for Decreased Cortical Oxygen Metabolism in Patients With Leukoaraiosis: Is Disconnection the Answer?
• Guidelines for Hypertension in the Elderly : 1999 Revised Version
• Asymptomatic Moyamoya Disease Associated With Coronary and Renal Artery Stenoses : A Case Report
• Cerebral blood flow and vascular response to hypercapnia in hypertensive patients with leukoaraiosis
• DECREASE IN ENDOTHELIUM DEPENDENT HYPOTENSION IN SPONTANEOUSLY HYPERTENSIVE RATS
• evidence-based practice guideline for the treatment of chronic kidney disease
• Maintaining high hemoglobin levels improved the left ventricular mass index and quality of life scores in pre-dialysis Japanese chronic kidney disease patients
• Insulin and Cardiovascular Diseases in Japanese Work-Site Population with Borderline to Mild Hypertension
• Acute Spontaneous Hemorrhagic Degeneration of the Thyroid Nodule with Subacute Thyroiditis-Like Symptoms and Laboratory Findings
• Effects of Lysosomal Protease Inhibitors on the Degradation of Acetylated Low Density Lipoprotein in Cultured Rat Peritoneal Macrophages
• Dementia and Other Risk Factors for Mortality in the Institutionalized Japanese Elderly
• Tonsillectomy and steroid pulse (TSP) therapy for patients with IgA nephropathy : a nationwide survey of TSP therapy in Japan and an analysis of the predictive factors for resistance to TSP therapy
• AGING GENERATES ENDOTHELIUM-DEPENDENT CONTRACTION IN VASCULAR SMOOTH MUSCLE OF NORMOTENSIVE WISTAR-KYOTO (WKY) AND SPONTANEOUSLY HYPERTENSIVE RATS (SHR) : Hypertension : 53 Annual Scientific Meeting, Japanese Circulation Society
• Central and Peripheral Mechanisms of the Enhanced Hypertension Following Long-term Salt Loading in Spontaneously Hypertensive Rats : THE 17th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
• Risk Factors for Methicillin-resistant Staphylococcus Aureus (MRSA) Urinary Tract Infection in a Geriatric Hospital : A Matched Case-control Study
• Central Infusion of _L-Arginine or Superoxide Dismutase Does Not Alter Areterial Pressure in SHR
• Effects of Salt-Loading on Membrane Potentials in Mesenteric Arteries of Spontaneously Hypertensive Rats
• Adenovirus-Mediated Gene Transfer to Cerebral Blood Vessels and Ischemic Brain : Perivascular Approach and Ischemic Threshold
• RELATIONSHIP AMONG HYPERISULINEMIA, BLOOD PRESSURE AND LIPID METABOLISM IN BORDERLINE TO MILD HYPERTENSION : Hypertension : 53 Annual Scientific Meeting, Japanese Circulation Society
• -504- HYPOTENSIVE ACTION OF CALCIUM ANTAGONIST AND BLOCKADE OF SYMPATHETIC NERVOUS SYSTEM AND VASOPRESSIN : COMPARISON BETWEEN NORMOTENSIVE AND DOCA-SALT HYPERTENSIVE RATS
• -493- CHANGES IN CSF AND SERUM SODIUM CONCENTRATION AND BLOOD PRESSURE IN DOCA-SALT HYPERTENSIVE RATS
• CONTRIBUTION OF SYMPATHETIC FUNCTION AND VASOPRESSIN AT THE VARIOUS STAGES OF INITIATION, DEVELOPMENT, AND MAINTENANCE OF DOCA-SALT HYPERTENSION IN RATS : Sympathetic Function : PROCEEDINGS OF THE 50th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION
• Blood Pressure and Sympathetic Nervous Function in Spontaneously Hypertensive Rats Derived from Breeders on Low Sodium Diet : THE 15th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
• DIAGNOSTIC RELIABILITY OF CAPTOPRIL TEST FOR PRIMARY ALDOSTERONISM : COMPARISON WITH OTHER SCREENING METHODS : Hypertension (II) : FREE COMMUNICATIONS (II) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• Pressure and Velocity Distributions along the Conveying Pipe in Vertical Pneumatic Riser at High Solids Ratio Transport of Powdery Material
• Measurement of Solid Velocity in the Vertical Pneumatic Transport of Powdery Material at a High Solid-loading Ratio : Fluids Engineering
• Cardiovascular and Sympathetic Responses to Dental Surgery with Local Anesthesia
• Suppression of Cardiac Sympathetic Nervous System during Dental Surgery in Hypertensive Patients
• Obesity Induced by Neonatal Monosodium Glutamate Treatment in Spontaneously Hypertensive Rats: An Animal Model of Multiple Risk Factors
• Brain Circulation Studies by External Counting of Intravenously Injected RISA : A Preliminary Report
• Chronic Myelogenous Leukemia That Occurred Two Years after the Diagnosis of Adult Still’s Disease
• Solitary Pontine Tuberculoma.
• Hepatitis B Surface Antigen and Antibody among Chronic Hemodialysis Patients in Fukuoka, Japan : A High Risk for Becoming Hepatitis B Virus Carriers

もっと見る 閉じる

スポンサーリンク