アルカリ金属の行動薬理学的研究-2-Aggressive behaviour発生時のマウス脳内のpolyamineの変動およびその行動に対するLiClの影響について

概要

論文の詳細を見る
Aggressive patterns such as mounting, attacking and vocalization appeared in aggressive mice induced by electro-shock (ES-mice), however, only attacking behavior was marked in aggressive mice, isolated for 3 weeks (IS-mice). In ES-mice, spermine markedly increased as compared with that of aggregated and nonaggressive mice, while NA, DA, 5-HT and spermidine were unchanged. In IS-mice, attacking intensity gradually increased in proportion to the period of isolation and increase in concentration of spermidine paralled the increase in attacking. Each amine remained unchanged in mice which were not aggressive even though isolation was carried out for 3 or 4 weeks. When LiCl (50 mg/kg) was injected i.p. into IS-mice twice a day for ten days, aggressive patterns completely disappeared on the 10th day. This chronic treatment with LiCI (50 mg/kg), further increased the spermine in IS-mice.
社団法人日本薬理学会の論文