Mitogenic Activity of Clostridium perfringens Enterotoxin in Human Peripheral Lymphocytes.
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概要
- 論文の詳細を見る
Clostridium perfringens enterotoxin (CPE) was found to possess interferon (IFN)-producing and mitogenic activities to human peripheral blood mononuclear cells. Both activities were demonstrated only in the T lymphocyte-rich fraction from healthy volunteers. The IFN produced appeared to be γ-type since the activity of the IFN was neutralized by antiserum against human IFN-γ. With formalin-treated CPE, the IFN-producing and mitogenic activities were weakly found. Similar findings were also obtained in the mouse lethality and cytotoxicity to Vero (African green monkey) cells, suggesting that the biological activities of the CPE molecule may be existing on the similar (or the same) sites. From these findings, human peripheral T cells may be one of useful reagents to study the mode of action of CPE since CPE was found to be a T cell mitogen which is supposed to be a superantigen.
- 公益社団法人 日本獣医学会の論文
著者
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Uemura Takashi
Department Of Applied Biological Science Science University Of Tokyo
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Nagata Kumiko
Department of Bacteriology and Hyogo College of Medicine
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OKAMURA Haruki
Department of Bacteriology, Hyogo College of Medicine
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KUNITOH Daisuke
Department of Veterinary Science, College of Agriculture, Osaka Prefecture University
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