Apoptosis of Enterocytes Induced by Inoculation of a Strain of Attaching and Effacing Escherichia coli and Verotoxin.
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概要
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When verotoxin (VT)-producing attaching and effacing Escherichia coli (AEEC, serotype O5: H-) were inoculated perorally into 10-day-old rabbits, attaching of the E. coli to enterocytes and effacing of their microvillous portion were observed extensively from the ileum to the colon. Subsequent apoptotic changes of the infected enterocytes were demonstrated by the terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-biotin nick end labeling (TUNEL) reaction and electron microscopy. Apoptosis was also induced in cultured Vero cells by inoculation of VT extracted from the AEEC. This study clarified that VT-producing AEEC induce apoptosis of enterocytes, causing mucosal damage.
- 公益社団法人 日本獣医学会の論文
著者
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MORI Koshi
Laboratory of Anatomy, Graduate School of Veterinary Medicine, Hokkaido University
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Iwanaga Toshihiko
Laboratories Of Anatomy Graduate School Of Veterinary Medicine Hokkaido University
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Mori Koshi
Laboratory Of Anatomy Department Of Biomedical Sciences School Of Veterinary Medicine Hokkaido Unive
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WADA Yoshihiro
Kamikawa Livestock Hygiene Service Center
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