Uptake of CDDP-containing Polymeric Micelles by Cells Using Particle Induced X-Ray Emission

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概要

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• Polymeric micelles loaded with cis-diamminedichloroplatinum(II), CDDP, (cisplatin micelles) enable higher accumulation in solid tumors and lower toxicities compared with CDDP alone. The combined use of cisplatin micelles with radiation is expected to enhance therapeutic effects and reduce side effects. The kinetics of cisplatin micelle uptake, however, have not been fully understood. Particle Induced X-Ray Emission has been employed in this study to measure the time transients of platinum in Chinese Hamster ovary cells. The results show that the platinum content of cells treated with cisplatin micelles increased more slowly than with CDDP alone, suggesting that cellular uptake could be controlled using micelles. The CDDP released from micelles was predominantly incorporated into the cells by diffusion. The uptake characteristics were further analyzed using micelles with different collapse rates. The results and techniques used in this study will be useful for designing an optimum treatment plan combining platinum-containing polymeric micelles and radiation in clinical applications.

• Journal of Radiation Research 編集委員会の論文

著者

• Konishi Teruaki

  Dept. Technical Support And Development National Institute Of Radiological Sciences

• Iso Hiroyuki

  Department of Behavior Science, Hyogo University of Health Sciences

• Mizuno Kazue

  Department of Nuclear Engineering and Management, The University of Tokyo

• ISHIKAWA Takahiro

  Department of Life Science and Biotechnology, Faculty of Life and Environmental Science, Shimane Uni

• KONISHI Teruaki

  Department of Life Science, Rikkyo University

• OIKAWA Masakazu

  Department of Technical Support and Development, National Institute of Radiological Sciences

• IMASEKI Hitoshi

  Department of Technical Support and Development, Fundamental Technology Center, National Institute o

• UESAKA Mitsuru

  Department of Nuclear Engineering and Management, School of Engineering, The University of Tokyo

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