Primary Ciliary Dyskinesia that Responded to Long-Term, Low-Dose Clarithromycin
スポンサーリンク
概要
- 論文の詳細を見る
A 46-year-old man was referred to our hospital with hemoptysis. He had been diagnosed with chronic sinusitis since childhood, but had received no treatment. Chest CT showed a diffuse centrilobular granular shadow and thickened bronchial walls. Otitis media and decreased spermatic motor ability were identified. In addition, electron microscopy of a biopsy specimen of the nasal mucosa showed a deficiency of inner dynein. Based on these clinical findings, primary ciliary dyskinesia (PCD) was diagnosed and successfully treated with long-term, low-dose clarithromycin. Although the effects of macrolide therapy remain controversial, long-term treatment with low-dose clarithromycin might confer clinical benefits upon patients with PCD.
著者
-
Sakamoto Noriho
The Second Department of Internal Medicine, Nagasaki University School of Medicine
-
Ishimatsu Yuji
The Second Department of Internal Medicine, Nagasaki University School of Medicine
-
Kadota Jun-ichi
Internal Medicine 2 Faculty Of Medicine Oita University
-
KAKUGAWA Tomoyuki
the Second Department of Internal Medicine, Nagasaki University School of Medicine
-
Kohno Shigeru
The Scientific Assembly For Infection And Tuberculosis Of The Japanese Respiratory Society
-
Ishii Hiroshi
Internal Medicine 2 Oita University Faculty Of Medicine
-
Yoshioka Daisuke
The Second Department of Internal Medicine, Nagasaki University School of Medicine
-
Mukae Hiroshi
Division of Respiratory Disease, University of Occupational and Environmental Health
関連論文
- Two Patients Who Developed Leptospirosis-Associated Acute Renal Failure within the Same Season
- PJ-655 Relationship between Initial R Wave in Lead aVR and Left Ventricular Wall Motion Abnormality in Old Anterior Myocardial Infarction(PJ110,ACS/AMI (Clinical/Pathophysiology) 1 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The
- OJ-130 Relationship between ST-segment Shift in Lead aVR and Angiographic Coronary Anatomy in Acute Anterior Myocardial Infarction(OJ22,ACS/AMI (Clinical/Pathophysiology) (IHD),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanes
- Elevated Serum Levels of Lysozyme in Desquamative Interstitial Pneumonia
- Echocardiographic Evaluation of Right Cardiac Function in Patients with Chronic Pulmonary Diseases
- Synchronized disappearance of serum HCV-RNA, anti-U1 RNP, anti-La/SS-B, and anti-Scl-70 in a patient with chronic hepatitis
- Comparison of Complement Fixation and Microimmunofluorescence Tests in Respiratory Infections Caused by Chlamydia and an Evaluation of the Serum Amyloid A Protein in Chlamydial Infections
- Combined Use of Clarithromycin and Antimycobacterial Agents in Mycobacterium avium Complex Chronic Pulmonary Infection
- Infections in Patients with Liver Cirrhosis and Hepatocellular Carcinoma
- Synergistic effect of ofloxacin and fluconazole against azole-resistant Candida albicans
- Evaluation of Sandwich ELISA Galactomannan Test in Samples of Positive LA Test and Positive Aspergillus Antibody
- Effect of sequential combination of amphotericin B and azole antifungal agents against Aspergillus fumigatus
- Elevated Levels of Tenascin-C in Patients with Cryptogenic Organizing Pneumonia
- Giant Cell Interstitial Pneumonia in a 15-year-old Boy
- Clinical Evaluation of 61 Patients with Pulmonary Aspergilloma
- Invasive Pulmonary Aspergillosis Diagnosed Early by Polymerase Chain Reaction Assay
- Detection of Mycobacterium tuberculosis in Preserved Tuberculous Lymph Nodes by Polymerase Chain Reaction
- Clinical Evaluation of Catheter-Related Fungemia and Bacteremia
- A Case in Which Stent Insertion is Considered to Have Triggered Contrast Medium-Induced Coronary Vasospasm
- PE-221 Association of Glucose Metabolism with the Severity of Obstructive Sleep Apnea in Patients with Obstructive Sleep Apnea(PE037,Obesity/SAS 1 (H),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Carvedilol Reduces the Severity of Central Sleep Apnea in Chronic Heart Failure(Heart Failure)
- Vasospastic Angina Likely Related to Cisplatin-containing Chemotherapy and Thoracic Irradiation for Lung Cancer
- Bronchoscopic Therapy for Mucosa-associated Lymphoid Tissue Lympohma of the Trachea
- The Multidrug Resistance-associated Protein Gene Confers Drug Resistance in Human Gastric and Colon Cancers
- A Prospective Study of Bronchoscopy for Endotracheobronchial Tuberculosis
- Chronic Bronchial Foreign Body Mimicking Peripheral Lung Tumor
- Acinar cell carcinoma of the pancreas associated with hypoglycemia: Involvement of "big" insulin-like growth factor-II
- Reduced Immune Function and Malnutrition in the Elderly
- A Case of Intravascular Large B-cell Lymphoma (IVLBCL) with no Abnormal Findings on Chest Computed Tomography Diagnosed by Random Transbronchial Lung Biopsy
- A Small Outbreak of Pulmonary Tuberculosis in Non-close Contact Patrons of a Bar
- Hepatic Artery Pseudoaneurysms in a Patient Treated for Miliary Tuberculosis
- Pulmonary Nocardia otitidiscaviarum Infection in a Patient with Chronic Respiratory Infection
- Type II Diabetes Mellitus and Primary Sjogren's Syndrome Complicated by Pleural Effusion
- Diffuse Alveolar Hemorrhage following Itraconazole Injection
- Plasma homocysteine level is unrelated to long-term cardiovascular events in patients with previous percutaneous coronary intervention
- PJ-597 Efficacy of Single Bolus Administration of Sodium Bicarbonate to Prevent Contrast-Induced Nephropathy in Patients with Renal Insufficiency Undergoing Coronary Procedure(PJ100,Kidney/Renal Circulation/CKD 5 (H),Poster Session (Japanese),The 73rd Ann
- PJ-030 Relationship between Serum Cystatin C and Cardio-Ankle Vascular Index in Type 2 Diabetic Patients(PJ005,Diabetes 1 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OJ-009 Relationship between Very Low Frequency Power of Heart Rate Variability during Sleep and the Severity of Obstructive Sleep Apnea(OJ02,Obesity/SAS (H),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Societ
- PJ-854 The Relationship between Time-domain Heart Rate Variability during Wakefulness and Sleep and the Severity of Obstructive Sleep Apnea(ECG / Body surface potential mapping / Holter(07)(A),Poster Session(Japanese),The 72nd Annual Scientific Meeting of
- PJ-848 Impaired Glucose Metabolism and the Severity of Obstructive Sleep Apnea in Patients with Obstructive Sleep Apnea(Diabetes / Obesity / Metabolic syndrome(16)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation
- PJ-758 Electrocardiographic Differentiation between Occlusion of the First Diagonal Branch and Occlusion of the Left Anterior Descending Coronary Artery(Acute myocardial infarction, clinical(diagnosis / treatment)(12)(IHD),Poster Session(Japanese),The 72n
- PJ-257 Relationship between Occlusion of the Sinus Node Artery and Sinus Arrest during Coronary Intervention for Proximal Right Coronary Artery Lesions(Coronary revascularization, PCI(18)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of
- PJ-150 Effects of Bolus Administration of Intravenous Sodium Bicarbonate before Undergoing Diagnostic Catheterization or Elective Percutaneous Coronary Intervention(Kidney/Renal circulation(05)(H),Poster Session(Japanese),The 72nd Annual Scientific Meetin
- OJ-144 Beta Blockers Attenuate the Association between Plasma BNP Level and the Severity of Central Sleep Apnea in Chronic Heart Failure(Heart failure, clinical(05)(M),Oral Presentation (Japanese),The 72nd Annual Scientific Meeting of the Japanese Circula
- OJ-111 The Relationship between the Estimated Glomerular Filtration Rate for Japanese and Future Cardiovascular Events in Outpatient with Coronary Artery Disease(Kidney/Renal circulation(02)(H),Oral Presentation(Japanese),The 72nd Annual Scientific Meetin
- OJ-020 The Relationship between Chronic Kidney Disease and Cardiovascular Events in Patient with Previous Percutaneous Coronary Intervention(Coronary revascularizaion, PCI(06)(IHD),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japa
- FRS-061 Carvedilol Reduces the Severity of Central Sleep Apnea in Chronic Heart Failure(Prognostic Biomarkers of Heart Failure(M),Featured Research Session,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- FRS-043 Determinants of ST-Segment Deviation in Lead aVR on Admission in ST-Segment Elevation Acute Anterior Myocardial Infarction(New Clinical Approach for Acute Myocardial Infarction(IHD),Featured Research Session,The 72nd Annual Scientific Meeting of t
- PJ-383 Relationship between the Severity of Central Sleep Apnea and 123I-metaiodobenzylguanidine Scintigraphic Findings in Patients with Chronic Heart Failure(Heart failure, clinical-11, The 71st Annual Scientific Meeting of the Japanese Circulation Socie
- PJ-343 The Incidental Detection of Cancers and Other Non-Cardiac Abnormalities on Coronary Multislice Computed Tomography(CT/DSA-08, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Diagnosis of Measles Pneumonia from Bronchoalveolar Lavage Fluid by Reverse-Transcriptase Polymerase Chain Reaction : Case Report
- Semi-Quantitative Non-Radioactive In Situ Hybridization and Its Clinical Application.
- Arteriovenous Malformation of the Bronchial Artery Showing Endobronchial Protrusion
- OJ-054 Relationship between Use of Beta Blocker and the Severity of Central Sleep Apnea in Chronic Heart Failure(Heart failure, clinical-2 (M) OJ9,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Soci
- Role of Autonomic Nervous Dysfunction in Electrocardio-graphic Abnormalities and Cardiac Injury in Patients With Acute Subarachnoid Hemorrhage
- Evaluation of Venous Thromboembolism and Coagulation-Fibrinolysis Markers in Inflammatory Bowel Disease
- OJ-146 Comparison of Sarpogrelate and Ticlopidine in Bare Metal Coronary Stent Implantation(Coronary revascularization, PCI-07, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Effect of Preinfarction Angina Pectoris on Myocardial Blush Grade After Reperfusion in First Anterior Wall Acute Myocardial Infarction(Clinical Investigation)
- Perioperative corticosteroids for intermittent and mild persistent asthma
- A retrospective study of the patients with positive ImmunoCard Mycoplasma test on an outpatient clinic basis
- PJ-663 Circadian Variation of Symptomatic Subacute Stent Thrombosis after Coronary Stent Implantation(Coronary revascularization, PCI-20 (IHD) PJ111,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Socie
- PJ-073 Valsartan Decreases the Expression of Adhesion Molecules on Circulating Monocytes in Patients with Hypertension(Hypertension, clinical-10 (H) PJ13,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation
- Increasing Threat of Fungemia in Japan
- Pontiac Fever: Non-Pneumonic Form of Legionellosis
- PJ-239 Relationship between Very Low Frequency of Heart Rate Variability During Wake and Sleep and the Severity of Obstructive Sleep Apnea(ECG/Body surface potential mapping/Holter-7, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-013 Plasma Brain Natriuretic Peptide Level is a Strong Predictor of Cardiac Events in Patients With Old Myocardial Infarction(Acute myocardial infarction, clinical (diagnosis/treatment)-6, The 71st Annual Scientific Meeting of the Japanese Circulation
- PJ-670 Usefulness of Sarpogrelate in Sirolimus-eluting Coronary Stenting(Coronary revascularization, PCI-22 (IHD) PJ113,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Mycobacterium avium Pleuritis in a Non-Immunocompromised Patient
- Successful Treatment of Chronic Pulmonary Thromboembolism by Long-term Intermittent Administration of Milrinone, a Phosphodiesterase-III Inhibitor
- Membranous Nephropathy and Kimura's Disease Manifesting a Hip Mass. A Case Report with Literature Review
- Community-acquired Chlamydia pneumoniae Pneumonia in Japan : A Prospective Multicenter Community-acquired Pneumonia Study
- Linezolid-resistant Staphylococcus aureus isolated from 2006 through 2008 at six hospitals in Japan
- A Rare Case of Extramedullary Plasmacytoma in the Mediastinum
- Limited Role of Auxiliary Endobronchial Biopsy in the Diagnosis of Japanese Patients with Sarcoidosis
- Association between coronary spastic angina pectoris and obstructive sleep apnea
- Disopyramide-induced Pneumonitis, Diagnosed by Lymphocyte Stimulation Test Using Bronchoalveolar Lavage Fluid
- Diffuse Liver Metastasis of Small Cell Lung Cancer Causing Marked Hepatomegaly and Fulminant Hepatic Failure
- Influence of the severity of obstructive sleep apnea on heart rate
- Sarcoidosis in a Patient with Systemic Sclerosis and Primary Biliary Cirrhosis
- GUIDELINES FOR SURGICAL THERAPY FOR PULMONARY NONTUBERCULOUS MYCOBACTERIAL DISEASES
- GUIDELINES FOR THE DIAGNOSIS OF PULMONARY NONTUBERCULOUS MYCOBACTERIAL DISEASES-2008
- Adalimumab-induced Interstitial Pneumonia with an Improvement of Pre-existing Rheumatoid Arthritis-associated Lung Involvement
- Giant Cell Interstitial Pneumonia in a 15-year-old Boy
- Desquamative Interstitial Pneumonia (DIP) in a Patient with Rheumatoid Arthritis: Is DIP Associated with Autoimmune Disorders?
- Primary Ciliary Dyskinesia that Responded to Long-Term, Low-Dose Clarithromycin
- Bacterial peritonitis due to duodenal perforation by a fish bone in an elderly peritoneal dialysis patient
- Clinical Characteristics of Tertiary Hospital Patients from Whom Acinetobacter calcoaceticus-Acinetobacter baumannii Complex Strains were Isolated
- An Elderly Patient with Diabetic Nephropathy Complicated by ANCA-associated Nephritis
- Nationwide surveillance of bacterial respiratory pathogens conducted by the Surveillance Committee of Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Clinical Microbiology in 2009 : general view of
- Unique Mutations of the Cystic Fibrosis Transmembrane Conductance Regulator Gene of Three Cases of Cystic Fibrosis in Nagasaki, Japan
- Cowfish (Umisuzume, Lactoria diaphana) Poisoning with Rhabdomyolysis
- The First Surgical Treatment Case of Pulmonary Mycobacterium malmoense Infection in Japan
- Mycobacterium intracellulare Pulmonary Infection which Co-existed and Mimicked Lung Cancer
- Two Cases of Lung Carcinoma with Osteoplastic Bone Metastasis.
- Superinfection of Chronic Necrotizing Pulmonary Aspergillosis by Mycobacterium tuberculosis.
- Fatal Pneumonia Caused by Corynebacterium Group JK after Treatment of Staphylococcus aureus Pneumonia.
- An Adult Case of Severe Chronic Active Epstein-Barr Virus Infection Syndrome.
- A Japanese Adult Case of Forme Fruste Cystic Fibrosis
- Tuberculous Osteomyelitis in the Ulna of a Patient Undergoing Hemodialysis
- An Outbreak of Legionnaires' Pneumonia in a Nursing Home.