Syntheses and Antibacterial Activities of Diterpene Catechol Derivatives with Abietane, Totarane and Podocarpane Skeletons against Methicillin-Resistant Staphylococcus aureus and Propionibacterium acnes
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概要
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Natural catechol, quinone and quinone methide diterpenes with abietane (15-deoxyfuerstione, taxodione) and totarane (dispermone, 12,13-dihydroxy-8,11,13-totaratriene-6-one), and podocarpane (nimbidiol, deoxynimbidiol) skeletons were synthesized using ortho-oxidation of phenol with meta-chlorobenzoyl peroxide. Minimum inhibitory activities of these diterpenes and previously synthesized natural diterpenes were measured against methicillin-resistant Staphylococcus aureus (MRSA) and Propionibacterium acnes, which cause serious skin infection associated with acne. Abietaquinone methide and 8,11,13-totaratriene-12,13-diol showed potent activities against S. aureus (MRSA) and P. acnes, and no serious toxicity by oral dose to mice.
- 社団法人 日本薬学会の論文
著者
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Tada Masahiro
Lab. Of Bioorganic Chemistry Tokyo Univ. Of Agriculture And Technol.
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Tada Masahiro
Laboratory Of Bio-organic Chemistry Tokyo University Of Agriculture And Technology
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Kurabe Jun
Laboratory of Bioorganic Chemistry, Tokyo University of Agriculture and Technology
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Yoshida Takashi
Laboratory of Bioorganic Chemistry, Tokyo University of Agriculture and Technology
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Ohkanda Tomoyuki
Laboratory of Bioorganic Chemistry, Tokyo University of Agriculture and Technology
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Matsumoto Yusuke
Laboratory of Bioorganic Chemistry, Tokyo University of Agriculture and Technology
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