Efficient ortho-Oxidation of Phenol and Synthesis of Anti-MRSA and Anti-VRE Compound Abietaquinone Methide from Dehydroabietic Acid
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概要
- 論文の詳細を見る
A quinone methide diterpene: abietaquinone methide, which possesses potent anti-methicillin-resistant Staphylococcus aureus (MRSA) and anti-vancomycin-resistant Enterococcus (VRE) activities, was synthesized via efficiently ortho-oxidation of ferruginol derived from industrially available dehydroabietic acid. ortho-Oxidation of phenols was developed to give mono esters of catechols using a stable diacyl peroxide, bis(4-chlorobenzoyl) peroxide (m-chlorobenzoyl peroxide: mCBPO) which was synthesized from meta-chlorobenzoic acid. Efficient one pot ortho-oxidation reaction of phenol with an adduct of mete-chloroperbenzoic acid (mCPBA) with dicyclohexylcarbodiimide (DCC) was also reported.
- 公益社団法人日本薬学会の論文
- 2006-10-01
著者
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Tada Masahiro
Lab. Of Bioorganic Chemistry Tokyo Univ. Of Agriculture And Technol.
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Tada Masahiro
Laboratory Of Bio-organic Chemistry Tokyo University Of Agriculture And Technology
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ISHIMARU Kosaku
Laboratory of Bioorganic Chemistry, Tokyo University of Agriculture and Technology
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Ishimaru Kosaku
Laboratory Of Bioorganic Chemistry Tokyo University Of Agriculture And Technology
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