Roles of Oral Bacteria in Cardiovascular Diseases — From Molecular Mechanisms to Clinical Cases: Treatment of Periodontal Disease Regarded as Biofilm Infection: Systemic Administration of Azithromycin
スポンサーリンク
概要
- 論文の詳細を見る
Periodontal disease as a biofilm infectious disease is considered. Periodontal disease–associated bacteria formed biofilm in periodontal pockets or on the surface of cementum. Planktonic bacteria from biofilm invade into periodontal tissues and lead to inflammation and destruction of tissues directly and indirectly by eliciting the host defense mechanism. Supragingival dental plaques (biofilm) are easily removed by professional mechanical tooth cleaning, while subgingival dental plaques and bacteria invading into periodontal tissues are difficult to remove. Therefore, the development of a method for periodontal disease based on the concept that regards periodontal disease as a biofilm infectious disease is needed. Hereby, I report the effect of antibiotics on an in vitro biofilm model of periodontal disease and the systemic administration of azithromycin for early-onset (aggressive) periodontitis like a treatment resistant periodontitis.
- 社団法人 日本薬理学会の論文
著者
関連論文
- Preventive Effects of a Kampo Medicine, Orento on Inflammatory Responses in Lipopolysaccharide Treated Human Gingival Fibroblasts
- Preventive Effects of a Kampo Medicine, Shosaikoto, on Inflammatory Responses in LPS-Treated Human Gingival Fibroblasts(Pharmacology)
- Effect of Cysteine Protease of Porphyromonas gingivalis on Adhesion Molecules in Gingival Epithelial Cells
- Salivary Amylase Activity of Rats Fed a Low Calcium Diet
- Measurement of Histatins in the Saliva of Healthy Humans
- Destruction of LPS Receptor by Porphyromonas gingivalis Protease is Prevented by Histatin 5, a Specific Protease Inhibitor
- Porphyromonas gingivalis Protease Degrades Cell Adhesion Molecules of Human Gingival Fibroblasts
- Expression and Nuclear Localization of p65 in Brain and Retina of Streptozotocin-induced Diabetic Rats with Hyperglycemia
- Effect of a Low Calcium Diet on the Levels of Protein Kinases Activity in Rat Parotid Glands
- Effect of a low calcium diet on the salivary amylase in weaning rats
- Development of Novel Therapy for Oral Diseases Using Kampo Medicines
- Transcriptional Regulation of the Salivary Histatin Gene : Finding of a Strong Positive Regulatory Element and Its Binding Protein
- Lipopolysaccharide-Treated Human Gingival Fibroblasts Continuously Produce PGE_2
- Search for chronic periodontitis-related gene by SNPs analysis(Poster Session,The 16th Annual Meeting of the Society for Hard Tissue Regenerative Biology in Matsumoto Dental University)
- Effect of Byakko-ka-ninjin-to and Gorei-san in STZ-induced diabetic saliva flow disorders mouse(Poster Session,The 16th Annual Meeting of the Society for Hard Tissue Regenerative Biology in Matsumoto Dental University)
- Cell type specific expression of the salivary histatin 3 gene(Poster Session,The 16th Annual Meeting of the Society for Hard Tissue Regenerative Biology in Matsumoto Dental University)
- SNPs analysis of the enamerin gene in severe dental caries of primary dentition period(Poster Session,The 16th Annual Meeting of the Society for Hard Tissue Regenerative Biology in Matsumoto Dental University)
- The effect of Sho-saiko-to (TJ-9) on human gingival fibroblasts(Oral Session,The 16th Annual Meeting of the Society for Hard Tissue Regenerative Biology in Matsumoto Dental University)
- Analysis of mutations of inflammatory cytokine and Toll-like receptor genes in periodontitis in Down syndrome patients
- Inhibition of Nifedipine-induced Proliferation of Cultured Human Gingival Fibroblasts by Saireito, a Chinese Herbal Medicine
- Effect of Anti-CD14 Antibody on Experimental Periodontitis Induced by Porphyromonas gingivalis Lipopolysaccharide
- LPS-stimulated Apert Syndrome Gingival Keratinocytes Show Markedly Suppressed Inflammatory Cytokine Production
- Effect of Histatin 5, a Specific Protease Inhibitor, on Cytotoxic Activity of Porphyromonas gingivalis Protease in Cultured Human Gingival Fibroblasts
- Effects of LPS and Protease from Porphyromonas gingivalis on Cultured Human Gingival Fibroblasts
- Effect of Actinobacillus actinomycetemcomitans Protease on Human Gingival Fibroblasts
- Increase of intracellular calcium concentration in MC3T3-E1 cells by stannous compound(Poster Session,The 16th Annual Meeting of the Society for Hard Tissue Regenerative Biology in Matsumoto Dental University)
- Analysis of mutations in the amelogenin and the enamelin genes in severe caries in Japanese pediatric patients
- Roles of Oral Bacteria in Cardiovascular Diseases — From Molecular Mechanisms to Clinical Cases: Treatment of Periodontal Disease Regarded as Biofilm Infection: Systemic Administration of Azithromycin
- Combined Effect of Capacitively Coupled Electric Field and Prostaglandin E_1 on the Promotion of Bone Formation around Dental Implants
- Effect of Pulsing Electromagnetic Fields on Gene Expression of Bone Morphogenetic Proteins in Cultured Human Osteoblastic Cell line
- Interleukin-8 Production by Human Gingival Fibroblasts in Response to Periodontopathic Bacterial Lipopolysaccharides and Prostaglandin E_2 In vitro.
- Effects of Melatonin on Prostaglandin E_2-induced Pro-inflammatory Cytokine Production in Human Gingival Fibroblasts
- Polymorphisms of the mannose-binding lectin gene MBL in periodontitis in patients with Down syndrome
- Genetic polymorphism of the salivary mucin gene MUC7 in severe caries in Japanese pediatric patients
- Roles of Oral Bacteria in Cardiovascular Diseases-From Molecular Mechanisms to Clinical Cases : Treatment of Periodontal Disease Regarded as Biofilm Infection : Systemic Administration of Azithromycin
- Preventive Effects of a Kampo Medicine, Hangeshashinto on Inflammatory Responses in Lipopolysaccharide-Treated Human Gingival Fibroblasts