A Case of Familial Amyloid Polyneuropathy due to Phe33Val TTR with Vitreous Involvement as the Initial Manifestation

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概要

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• We report a 61-year-old Japanese woman with transthyretin (TTR) Val33-related familial amyloid polyneuropathy (FAP). She presented with late-onset, vitreous involvement as the initial manifestation, slow development of polyneuropathy, cardiomyopathy, and severe autonomic failure without carpal tunnel syndrome. Liver transplantation was performed and her postoperative course was stable. Taken together with previous reports, vitreous opacities seem to be common to Val33 FAP. Vitreous amyloidosis is usually seen in combination with the involvement of other visceral organs. The findings in the present case emphasize that vitreous opacities could be the first manifestation of FAP.

著者

• NARAI HISASHI

  Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University

• OMORI Nobuhiko

  Department of Neurology, National Hospital Organization Okayama Medical Center

• Ueda Mitsuharu

  Department Of Diagnostic Medicine Graduate School Of Medical And Pharmaceutical Sciences Kumamoto Un

• Ando Yukio

  Department Of Diagnostic Medicine Graduate School Of Life Sciences Kumamoto University

• Abe Koji

  Department Of Applied Chemistry Graduate School Of Engineering Tohoku University

• Manabe Yasuhiro

  Department Of Neurology Graduate School Of Medicine And Dentistry Okayama Univeristy

• Tanaka Tomotaka

  Department of Neurology, National Hospital Organization Okayama Medical Center

• Kono Syoichiro

  Department of Neurology, National Hospital Organization Okayama Medical Center

• Fujii Daiki

  Department of Neurology, National Hospital Organization Okayama Medical Center

• Narai Hisashi

  Department of Neurology, National Hospital Organization Okayama Medical Center

• Sakai Yasuko

  Department of Neurology, National Hospital Organization Okayama Medical Center

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