Histological Study of Right Ventricle-Pulmonary Artery Valved Conduit Implantation (RPVC) in Dogs with Pulmonic Stenosis
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概要
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We examined whether right ventricle-pulmonary artery valved conduit (RPVC) implantation can overcome the disadvantages of current procedures for pulmonic stenosis (PS). We histologically evaluated the feasibility of RPVC using a homograft in PS model dogs. Eight dogs underwent pulmonary artery banding (PAB) and then 12 weeks later were assigned to PAB (n=4) or PAB+RPVC (n=4) groups. Dogs in the PAB group received no treatment throughout the experimental period, whereas the PAB+RPVC group underwent RPVC. At 1 year after PAB, hearts and conduits were explanted from euthanized dogs and histologically evaluated. The ratios (%) of myocardial fibrosis on right ventricle (RV) epicardial, median and endocardial layers were significantly lower in the PAB+RPVC, than in the PAB group. The ratio of myocardial fibrosis on left ventricular (LV) epicardial and endocardial layers were significantly lower in the PAB+RPVC, than in the PAB group. Neo-intimal thickness in the anastomosis areas of the Denacol and PAB+RPVC groups was 42.77 ± 30.19 and 88.30 ± 27.24 μm, respectively, with no significant differences between the groups. Calcification and neo- intima hypertrophy were not obvious in the valve area. Immunohistological staining showed that the internal surface of the anastomosis and intermediate areas were positive for endothelial cells. We concluded that RPVC using a bioprosthetic graft can apparently overcome the disadvantages of current procedures for pulmonic stenosis.
著者
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Saida Yuuto
Department Of Veterinary Surgery Tokyo University Of Agriculture And Technology
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TANAKA Ryou
Department of Veterinary Surgery, Tokyo University of Agriculture and Technology
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Yamane Yoshihisa
Department Of Veterinary Surgery Tokyo University Of Agriculture And Technology
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HOSHI Katsuichiro
Mitsuke Animal Hospital
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SODA Aiko
Department of Veterinary Surgery, Tokyo University of Agriculture and Technology
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FUKUSHIMA Ryuji
Department of Veterinary Surgery, Faculty of Agriculture, Tokyo University of Agriculture and Techno
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HIRA Satoshi
Department of Veterinary Surgery, Faculty of Agriculture, Tokyo University of Agriculture and Techno
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IIZUKA Tomoya
Department of Veterinary Surgery, Faculty of Agriculture, Tokyo University of Agriculture and Techno
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ISHIKAWA Taisuke
Department of Veterinary Surgery, Faculty of Agriculture, Tokyo University of Agriculture and Techno
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NISHIMURA Taiki
Department of Veterinary Surgery, Faculty of Agriculture, Tokyo University of Agriculture and Techno
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Soda Aiko
Department Of Veterinary Surgery Tokyo University Of Agriculture And Technology
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Ishikawa Taisuke
Department of Molecular Pathogenesis, Medical Research Institute, and Division of Genetic Regulation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
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SAIDA Yuuto
Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University
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TANAKA Ryou
Department of Veterinary Surgery, Faculth of Agriculture, Tokyo University of Agriculture and Technology
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