Echocardiographic Estimation of Left Atrial Pressure in Beagle Dogs with Experimentally-Induced Mitral Valve Regurgitation
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概要
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Non-invasive and immediate estimation of left atrial pressure (LAP) is very useful for the management of mitral regurgitation (MR), and many reports have assessed echocardiographic estimations of LAP to date. However, it has been unclear of which examination and evaluate article possess the best accuracy for the MR severity. The present research aims to establish the echocardiographic estimation equation of LAP that is well applicable for clinical MR dogs. After the chordae tendineae rupture was experimentally induced via left atriotomy in six healthy beagle dogs (three males and three females, two years old, weighing between 9.8 to 12.8 kg), a radio telemetry transmitter catheter was inserted, which allows the continuous recordings of LAP without the use of sedation. Approximately 5 weeks after the surgery, echocardiographic examination, indirect blood pressure measurement, measurement of plasma atrial natriuretic peptide (ANP) and LAP measurement by way of the radio telemetry system was performed simultaneously. Subsequently, simple linear regression equations between LAP and each variable were obtained, and the equations were evaluated whether to be applicable for clinical MR dogs. As a result, the ratio of early diastolic mitral flow to early diastolic lateral mitral annulus velocity (E/Ea) had the strongest correlation as maximum LAP=7.03*(E/Ea)－54.86 (r=0.74), and as mean LAP=4.94*(E/Ea)－40.37 (r=0.70) among the all variables. Therefore, these two equations associated with E/Ea should bring more precise and instant estimations of maximum and mean LAP in clinical MR dogs.
著者
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FUKUSHIMA Ryuji
Department of Veterinary Surgery, Faculty of Agriculture, Tokyo University of Agriculture and Techno
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HIRA Satoshi
Department of Veterinary Surgery, Faculty of Agriculture, Tokyo University of Agriculture and Techno
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NISHIMURA Taiki
Department of Veterinary Surgery, Faculty of Agriculture, Tokyo University of Agriculture and Techno
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Suzuki Shuji
Department Of Gastroenterology Hachioji Digestive Disease Hospital
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TANAKA Ryou
Department of Veterinary Surgery, Faculty of Agriculture, Tokyo University of Agriculture and Technology
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ISHIKAWA Taisuke
Department of Veterinary Surgery, Faculty of Veterinary Medicine, Tokyo University of Agriculture and Technology
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Ishikawa Taisuke
Department of Molecular Pathogenesis, Medical Research Institute, and Division of Genetic Regulation, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
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MIYAISHI Yuka
Animal Clinic Kobayashi
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HAMABE Lina
Department of Veterinary Surgery, Faculty of Veterinary Medicine, Tokyo University of Agriculture and Technology
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TANAKA Ryou
Department of Veterinary Surgery, Faculth of Agriculture, Tokyo University of Agriculture and Technology
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Suzuki Shuji
Department of Cardiology, Osaka Medical College, Japan
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HAMABE Lina
Department of Veterinary Surgery, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3–5–8 Saiwai-cho, Fuchu, Tokyo 183–8509, Japan
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NISHIMURA Taiki
Department of Veterinary Surgery, Faculty of Veterinary Medicine, Tokyo University of Agriculture and Technology
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FUKUSHIMA Ryuji
Department of Veterinary Surgery, Faculty of Veterinary Medicine, Tokyo University of Agriculture and Technology
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TANAKA Ryou
Department of Veterinary Surgery, Faculty of Veterinary Medicine, Tokyo University of Agriculture and Technology
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SUZUKI Shuji
Department of Veterinary Surgery, Faculty of Veterinary Medicine, Tokyo University of Agriculture and Technology
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HIRA Satoshi
Department of Veterinary Surgery, Faculty of Veterinary Medicine, Tokyo University of Agriculture and Technology
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