Short-Term Performance of Mitral Valve Replacement with Porcine Bioprosthetic Valves in Dogs
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概要
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Porcine bioprosthetic valves cross-linked with glutaraldehyde and polyepoxy compound were newly developed for mitral valve replacement (MVR) in dogs. Five beagle dogs were performed a left thoracotomy and underwent MVR using the porcine bioprosthetic valves during cardiopulmonary bypass (CPB). A vein catheter inserted into right atrium and a vent catheter inserted into the right ventricle to drain. The hemodynamic conditions of CPB were excellent during surgery. The left atrial pressure was measured before and after MVR; there was no significant difference and it was normal. Thrombosis and the prosthetic valve regurgitation were not observed one week after MVR. Pressure half time (PHT) prolonged significantly (P<0.05) from 31.40 ± 4.0 msec presurgery to 99.20 ± 19.4 msec at seven days after MVR, although it indicated the normal range as the bioprosthetic valve. The symptom of the prosthetic valve failure was not observed. This study indicated that the MVR using porcine bioprosthetic valves under CPB might have been effective in dogs as a short-term evaluation.
- 公益社団法人 日本獣医学会の論文
著者
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TAKASHIMA Kazuaki
Animal Clinical Research Foundation
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YAMANE Yoshihisa
Animal Clinical Research Foundation
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Soda Aiko
Department Of Veterinary Surgery Tokyo University Of Agriculture And Technology
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TANAKA Ryou
Department of Veterinary Surgery, Faculth of Agriculture, Tokyo University of Agriculture and Technology
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