Synthesis and Evaluation of Pyrrolin-2-one Compounds, a Series of Plasminogen Activator Inhibitor-1 Inhibitors
スポンサーリンク
概要
- 論文の詳細を見る
A novel series of furan-2-one and pyrrolin-2-one derivatives having PAI-1 (plasminogen activator inhibitor-1) inhibitory activity were synthesized and evaluated for their antithrombotic activity in a rat arterial thrombosis model. Among the synthesized compounds, 5f (T-1776Na) was found to have good selectivity for PAI-1 over other enzymes and high antithrombotic activity.
- 社団法人 日本薬学会の論文
著者
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大谷 博司
東北大学学際科学研究センター
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大谷 博司
Dep. Of Materials Sci. And Engineering Kyushu Inst. Of Technol.
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Miyazaki Hiroshi
Medicinal Chemistry Laboratory, Mitsubishi Tanabe Pharma Co., Ltd.
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Ogiku Tsuyoshi
Medicinal Chemistry Laboratory, Mitsubishi Tanabe Pharma Co., Ltd.
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Sai Hiroshi
Medicinal Chemistry Laboratory, Mitsubishi Tanabe Pharma Co., Ltd.
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Moritani Yasunori
Medicinal Chemistry Laboratory, Mitsubishi Tanabe Pharma Co., Ltd.
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Ohtani Akio
Pharmacology Laboratory, Mitsubishi Tanabe Pharma Co., Ltd.
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Ohmizu Hiroshi
Medicinal Chemistry Laboratory, Mitsubishi Tanabe Pharma Co., Ltd.
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Ogiku Tsuyoshi
Medicinal Chemistry Lab. Mitsubishi Tanabe Pharma Corp.
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Ohmizu Hiroshi
Medicinal Chemistry Lab. Mitsubishi Tanabe Pharma Co. Ltd.
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Ohtani Akio
Pharmacology Lab. Mitsubishi Tanabe Pharma Co. Ltd.
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Ohtani Hiroshi
Third Department Of Internal Medicine Akita University School Of Medicine
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Ohtani H
Department Of Astrophysics Faculty Of Science Kyoto University
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