Imidapril, an Angiotensin-Converting Enzyme Inhibitor, Inhibits Thrombosis via Reduction in Aortic Plasminogen Activator Inhibitor Type-1 Levels in Spontaneously Hypertensive Rats

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概要

• 論文の詳細を見る

• It is known that angiotensin II (Ang II) exerts an antifibrinolytic effect by stimulating synthesis of plasminogen activator inhibitor type-1 (PAI-1), a specific inhibitor of tissue plasminogen activator (t-PA). The aim of this study was to compare the antithrombotic potency of imidapril, an angiotensin-converting enzyme (ACE) inhibitor, and candesartan, an angiotensin II type 1 (AT_1) receptor antagonist, in a model of arterial thromboss in spontaneously hypertensive rats (SHRs).Oral treatment with 5 mg/kg imidapril 1 h before induction of thrombosis resulted in a significant reduction in thrombus weight, whereas candesartan did not affect thrombus weight the same treatment conditions. Candesartan lowered blood pressure to the same degree as in the imidapril-treated rats. Imidapril not only reduce the serum and aortic ACE activities, but also reduced aortic PAI-1 protein levels, while candesartan had no effect on theses.These results suggest that imidapril, but not the AT_1 receptor antagonist, candesartan, enhances fibrinolysis via a reduction of aortic PAI-1 levels by inhibiting ACE and prevents thrombus formation in SHRs.

• 公益社団法人日本薬学会の論文
• 1999-08-15

著者

• Ohtani Akio

  Pharmacology Lab. Mitsubishi Tanabe Pharma Co. Ltd.

• ODAWARA Akio

  Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd.

• Odawara Akio

  Discovery Research Laboratory Tanabe Seiyaku Co. Ltd.

• Mitsui Takashi

  Discovery Research Laboratory Tanabe Seiyaku Co. Ltd.

• CHISHIMA Susumu

  Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd.,

• OHTANI Akio

  Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd.,

• Chishima Susumu

  Discovery Research Laboratory Tanabe Seiyaku Co. Ltd.

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• In Vitro Inhibitory Effects of the Optical Isomers and Metabolites of Fluvastatin on Copper Ion-Induced LDL Oxidation
• Imidapril, an Angiotensin-Converting Enzyme Inhibitor, Inhibits Thrombosis via Reduction in Aortic Plasminogen Activator Inhibitor Type-1 Levels in Spontaneously Hypertensive Rats

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