Synthesis of 1,4-Diphenylbutadiene Derivatives : Novel Inducer of Tissue-Type Plasminogen Activator (t-PA) in Cultured Bovine Endothelial Cells
スポンサーリンク
概要
- 論文の詳細を見る
(E, E)-1, 4-Diphenylbutadiene derivatives were synthesized by utilizing the Stobbe reaction of dimethyl succinate as a key step. Their stereoisomers were also synthesized stereoselectively by means of the cross-coupling reaction of the vinylstannanes and the vinylbromides, which were obtained from the propiolic acid esters by stereoselective hydrostannation, as a key step. To discover novel stimulators of fibrinolysis in vascular endothelial cells, the synthesized compounds were added to cultured bovine endothelial cells to determine the activity of the plasminogen activator in the conditioned medium. Of the synthesized compounds, three compounds were found to stimulate the activity of the plasminogen activator in endothelial cells. In addtition, these compounds inhibited thrombus formation in a rat model of venous thrombosis.
- 社団法人日本薬学会の論文
- 2006-12-01
著者
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大谷 博司
東北大学学際科学研究センター
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大谷 博司
Dep. Of Materials Sci. And Engineering Kyushu Inst. Of Technol.
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Ogiku Tsuyoshi
Medicinal Chemistry Laboratory, Mitsubishi Tanabe Pharma Co., Ltd.
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Ohmizu Hiroshi
Medicinal Chemistry Laboratory, Mitsubishi Tanabe Pharma Co., Ltd.
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SAI Hiroshi
Clinical Research Division, Tanabe Seiyaku Co., Ltd.
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OHTANI Akio
Strategic Research Planning & Management Division, Tanabe Seiyaku Co., Ltd.
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Ogiku Tsuyoshi
Medicinal Chemistry Lab. Mitsubishi Tanabe Pharma Corp.
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Ohmizu Hiroshi
Medicinal Chemistry Lab. Mitsubishi Tanabe Pharma Co. Ltd.
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Ohtani Akio
Pharmacology Lab. Mitsubishi Tanabe Pharma Co. Ltd.
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Ohtani Hiroshi
Third Department Of Internal Medicine Akita University School Of Medicine
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Ohtani H
Department Of Astrophysics Faculty Of Science Kyoto University
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